CHEMBRDG-BB 5245801

Base Information

• Chemical Name: CHEMBRDG-BB 5245801
• CAS No.: 57785-36-1
• Molecular Formula: C₁₀H₁₂BrNO₂
• Molecular Weight: 258.115
• Hs Code.: 2934999090
• Mol file: 57785-36-1.mol

Synonyms:CHEMBRDG-BB 5245801;1-(5-BROMO-2-FUROYL)PIPERIDINE;1-(5-bromo-2-furoyl)piperidine(SALTDATA: FREE)

Chemical Property of CHEMBRDG-BB 5245801

Chemical Property:

• Vapor Pressure: 4.38E-05mmHg at 25°C
• Boiling Point: 350.5°C at 760 mmHg
• Flash Point: 165.8°C
• PSA: 33.45000
• Density: 1.487g/cm³
• LogP: 2.60610

Purity/Quality:

95% ^*data from raw suppliers

(5-Bromofuran-2-yl)(piperidin-1-yl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMBRDG-BB 5245801

There total 8 articles about CHEMBRDG-BB 5245801 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

piperidine (110-89-4) + N-benzyl-5-bromo-N-tosylfuran-2-carboxamide → (5-bromofuran-2-yl)(piperidin-1-yl)methanone (57785-36-1)

Guidance literature:

In ethanol; at 45 ℃; chemoselective reaction; Sealed tube;

DOI:10.1055/s-0037-1610664

Reference yield: 76.0%

piperidine (110-89-4) + ethyl 5-bromo-2-furoylmalonate (157642-07-4) → (5-bromofuran-2-yl)(piperidin-1-yl)methanone (57785-36-1)

Guidance literature:

In acetonitrile; for 8h;

DOI:10.1135/cccc19941400

Reference yield: 59.0%

(furan-2-yl)(piperidin-1-yl)methanone (26163-41-7) → (5-bromofuran-2-yl)(piperidin-1-yl)methanone (57785-36-1)

Guidance literature:

With dipotassium peroxodisulfate; lithium bromide; In 1,2-dichloro-ethane; at 80 ℃; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1002/cjoc.202000303

upstream raw materials:

piperidine

5-bromofuran-2-carbonyl chloride

ethyl 5-bromo-2-furoylmalonate

5-bromo-furan-2-carboxylic acid