Chemical Property of Psoralen
Chemical Property:
- Appearance/Colour:Crystalline solid
- Vapor Pressure:1.91E-05mmHg at 25°C
- Melting Point:160-162 °C
- Refractive Index:1.667
- Boiling Point:362.6 °C at 760 mmHg
- Flash Point:173.1 °C
- Density:1.389 g/cm3
- Storage Temp.:2-8°C
- Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- Water Solubility.:65.16mg/L(25 oC)
- XLogP3:2.3
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:0
- Exact Mass:186.031694049
- Heavy Atom Count:14
- Complexity:284
- Purity/Quality:
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more than 96%,98% *data from raw suppliers
Psoralen *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xn
- Statements:
22-36/37/38
- Safety Statements:
26
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Drug Classes:Dermatologic Agents, Psoriasis Agents
- Canonical SMILES:C1=CC(=O)OC2=CC3=C(C=CO3)C=C21
- Recent ClinicalTrials:Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer
- Recent NIPH Clinical Trials:Efficacy and safety of bexarotene or bexarotene plus phototherapy in CTCL
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Description
Psoralen is a kind of naturally occurring furocoumarin. It is naturally occurred in the seeds of Psoralea corylifolia as well as in the common fig, celery, parsley, West Indian Satinwood and all citrus fruits. It is capable of binding to DNA via single- and double-strand cross-linking upon photoactivation with UV radiation. It can intercalate with DNA, blocking its synthesis and cell division. For this reason, it is an important mutagen and can be used in related molecular biology studies. It also exhibits anti- proliferative, anti-allergenic and anti-histamine functions. It can also be used in PUVA treatment for skin diseases such as psoriasis, eczema and vitiligo. It is also effective tanning activator in sunscreens. Some of its derivatives, e.g. amino-psoralen, amotosalen HCl, can even inactivate pathogens in blood products.
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Uses
Use as photochemical probe in biological systems Psoralens are phytoalexins; they are used by plants in a defensive response to attacks by fungi and insects. They have also shown photosensitizing and phototoxic effects in animals and humans and have
been used in photochemotherapy for management of vitiligo, psoriasis, and mycosis fungoides. Used as photochemical probe in biological systems. As photochemical probe in biological systems: P.-S. Song, C.-N. Ou, Ann. N.Y. Acad. Sci. 346, 355 (1980).
