3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic Acid

Base Information

Chemical Name:3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic Acid
CAS No.:869472-64-0
Molecular Formula:C₁₇H₁₄FNO₂
Molecular Weight:283.302
Hs Code.:
European Community (EC) Number:858-148-4
Mol file:869472-64-0.mol

Synonyms:3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic Acid;869472-64-0;3-(2-(4-Fluorophenyl)-1H-indol-3-yl)propanoic acid;SCHEMBL22118464;MFCD06660846;AKOS000122831;AT23605;CS-0234733;EN300-14651;J-511455;3-(2-(4-Fluorophenyl)-1H-indol-3-yl)propanoicacid;Z104378210;3-[2-(4-Fluorophenyl)-1H-indol-3-yl]propanoic acid, AldrichCPR

Suppliers and Price of 3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-(2-(4-Fluorophenyl)-1H-indol-3-yl)propanoicacid 97%
1g
$ 301.00

Chemenu
3-(2-(4-Fluorophenyl)-1H-indol-3-yl)propanoicacid 95%+
1g
$ 284.00

AK Scientific
3-[2-(4-Fluorophenyl)-1H-indol-3-yl]propanoicAcid
5g
$ 1046.00

Total 3 raw suppliers

Chemical Property of 3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic Acid

Chemical Property:

Boiling Point:527.0±45.0 °C(Predicted)
PKA:4.60±0.10(Predicted)
Density:1.315±0.06 g/cm3(Predicted)
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:283.10085685
Heavy Atom Count:21
Complexity:368

Purity/Quality:

99% ^*data from raw suppliers

3-(2-(4-Fluorophenyl)-1H-indol-3-yl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=C(N2)C3=CC=C(C=C3)F)CCC(=O)O

Technology Process of 3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic Acid

There total 8 articles about 3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: methyl 3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoate

: 869472-64-0
3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at -10 - 20 ℃; for 16h;

Reference yield: 93.0%

: 59-88-1
phenylhydrazine hydrochloride

: 149437-76-3
5-(4-fluorophenyl)-5-oxopentanoic acid

: 869472-64-0
3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic acid

Guidance literature:: With acetic acid; zinc(II) chloride; at 100 ℃; for 3h;

Reference yield:

: 120-72-9
indole

: 869472-64-0
3-[2-(4-fluorophenyl)-1H-indol-3-yl]propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; palladium diacetate / 16 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 40 °C

3: hydrogen; palladium on activated charcoal / ethyl acetate / 2 h / 20 °C

4: lithium hydroxide monohydrate / methanol; water; tetrahydrofuran / 16 h / -10 - 20 °C

With lithium hydroxide monohydrate; palladium on activated charcoal; hydrogen; palladium diacetate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;