N-(2-Pyridyl)oxamic Acid

Base Information

• Chemical Name: N-(2-Pyridyl)oxamic Acid
• CAS No.: 13120-39-3
• Molecular Formula: C7H6N2O3
• Molecular Weight: 166.13414
• Mol file: 13120-39-3.mol

Synonyms:N-(2-Pyridyl)oxamic Acid;2-Oxo-2-(2-pyridinylaMino)acetic Acid

Chemical Property of N-(2-Pyridyl)oxamic Acid

Chemical Property:

• Melting Point: 196-198℃
• PKA: -0.71±0.20(Predicted)
• PSA: 79.29000
• Density: 1.505±0.06 g/cm3(Predicted)
• LogP: 0.17770
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

N-(2-Pyridyl)oxamicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Tenoxicam (T019500). A degradation product and pathway of Lornoxicam.

Technology Process of N-(2-Pyridyl)oxamic Acid

There total 3 articles about N-(2-Pyridyl)oxamic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (pyridin-2-ylcarbamoyl)formate (54166-60-8) → N-(pyridyl)oxamic acid (13120-39-3)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.bmcl.2003.12.106

Reference yield:

2-aminopyridine (504-29-0) → N-(pyridyl)oxamic acid (13120-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

2: aq. LiOH / dioxane / 1 h / 20 °C

With lithium hydroxide; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm050307e

Reference yield:

→ N-(pyridyl)oxamic acid (13120-39-3)

Guidance literature:

Nitroso-(pyridyl-2-amino)-essigsaeure, Acetanhydrid;

DOI:10.1246/bcsj.33.1392

upstream raw materials:

methyl (pyridin-2-ylcarbamoyl)formate

2-aminopyridine

Refernces

• 1、 Linton, Steven D.,Aja, Teresa,Allegrini, Peter R.,Deckwerth, Thomas L.,Diaz, Jose-Luis,Hengerer, Bastian,Herrmann, Julia,Jahangiri, Kathy G.,Kallen, Joerg,Karanewsky, Donald S.,Meduna, Steven P.,Nalley, Kip,Robinson, Edward D.,Roggo, Silvio,Rovelli, Giorgio,Sauter, Andre,Sayers, Robert O.,Schmitz, Albert,Smidt, Robert,Ternansky, Robert J.,Tomaselli, Kevin J.,Ullman, Brett R.,Wiessner, Christoph,Wu, Joe C.. "Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke". . p. 2685 - 2691. Retrieved 2007/10/03.