2-(3-CHLOROPHENYL)ETHYL CYCLOPENTYL KETONE

Base Information

• Chemical Name: 2-(3-CHLOROPHENYL)ETHYL CYCLOPENTYL KETONE
• CAS No.: 625445-70-7
• Molecular Formula: C14H17ClO
• Molecular Weight: 236.741
• Hs Code.: 2914700090
• Mol file: 625445-70-7.mol

Synonyms:2-(3-CHLOROPHENYL)ETHYL CYCLOPENTYL KETONE

Chemical Property of 2-(3-CHLOROPHENYL)ETHYL CYCLOPENTYL KETONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 339.194°C at 760 mmHg
• Flash Point: 196.899°C
• PSA: 17.07000
• Density: 1.132g/cm³
• LogP: 4.03190

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Chlorophenyl)ethylcyclopentylketone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-CHLOROPHENYL)ETHYL CYCLOPENTYL KETONE

There total 3 articles about 2-(3-CHLOROPHENYL)ETHYL CYCLOPENTYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-bromo-3-chlorobenzene (108-37-2) + (+/-)-1-cyclopentylprop-2-en-1-ol (87453-54-1) → 3-(3-chloro-phenyl)-1-cyclopentyl-propan-1-one (625445-70-7)

Guidance literature:

With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 4h;

Reference yield:

3-chlorohydrocinnamic acid (21640-48-2) → 3-(3-chloro-phenyl)-1-cyclopentyl-propan-1-one (625445-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: PPh₃ / CH₂Cl₂ / 20 °C

2: tetrahydrofuran / -78 °C

With triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2006.06.065

Reference yield:

3-(3-chloro-phenyl)-thiopropionic acid S-pyridin-2-yl ester + cyclopentylmagnesium bromide (33240-34-5) → 3-(3-chloro-phenyl)-1-cyclopentyl-propan-1-one (625445-70-7)

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1016/j.bmcl.2006.06.065

upstream raw materials:

1-bromo-3-chlorobenzene

(+/-)-1-cyclopentylprop-2-en-1-ol

cyclopentylmagnesium bromide

3-chlorohydrocinnamic acid

Refernces

• 1、 -. "INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME". Page/Page column 50-51. . Retrieved 2010/02/07.