(S)-3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (S)-3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 1187931-76-5
• Molecular Formula: C11H18N2O2
• Molecular Weight: 210.27
• Hs Code.: 2933990090
• Mol file: 1187931-76-5.mol

Synonyms:3(S)-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(S)-3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl (S)-3-cyanomethylpyrrolidine-1-carboxylate

Chemical Property of (S)-3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 327.4±15.0 °C(Predicted)
• PKA: -2.14±0.40(Predicted)
• PSA: 53.33000
• Density: 1.062±0.06 g/cm3(Predicted)
• LogP: 2.09498
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl3-(Cyanomethyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 4 articles about (S)-3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.16%

sodium cyanide (773837-37-9) + tert-butyl (S)-3-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate (1391730-27-0,114214-70-9) → tert-butyl (S)-3-(cyanomethyl)pyrrolidine-1-carboxylate (1187931-76-5,142253-46-1)

Guidance literature:

In dimethyl sulfoxide; at 100 ℃;

Reference yield:

sodium cyanide (773837-37-9) + tert-butyl (R)-3-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate (330797-71-2,114214-70-9) → tert-butyl (S)-3-(cyanomethyl)pyrrolidine-1-carboxylate (1187931-76-5,142253-46-1)

Guidance literature:

sodium cyanide; tert-butyl (R)-3-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate; In dimethyl sulfoxide; at 100 ℃; for 4h;

With iron(II) sulfate; In water; dimethyl sulfoxide; at 20 ℃; for 8h;

Reference yield:

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate (199174-24-8) → tert-butyl (S)-3-(cyanomethyl)pyrrolidine-1-carboxylate (1187931-76-5,142253-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: dimethyl sulfoxide / 100 °C

With triethylamine; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

sodium cyanide

tert-butyl (R)-3-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

tert-butyl (S)-3-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate

Downstream raw materials:

(R)-3-carboxymethyl-pyrrolidin-1-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1187931-76-5 (S)-3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send