1-cyclopropyl-6-fluoro-1,4-dihydro-7-((4aR,7aS)-octahydropyrrolo [3,4-b]pyridin-6-yl)-8-Methoxy-4-oxoquinoline-3-carboxylic acid

Base Information

• Chemical Name: 1-cyclopropyl-6-fluoro-1,4-dihydro-7-((4aR,7aS)-octahydropyrrolo [3,4-b]pyridin-6-yl)-8-Methoxy-4-oxoquinoline-3-carboxylic acid
• CAS No.: 1394029-14-1
• Molecular Formula: C21H24FN3O4
• Molecular Weight: 401.4313632
• Hs Code.: 2933497050
• Mol file: 1394029-14-1.mol

Synonyms:1-cyclopropyl-6-fluoro-1,4-dihydro-7-((4aR,7aS)-octahydropyrrolo [3,4-b]pyridin-6-yl)-8-Methoxy-4-oxoquinoline-3-carboxylic acid;(4R,7R)-Moxifloxacin Hydrochloride 3;Moxifloxacin Impurity 11;Moxifloxacin Impurity 12;Moxifloxacin Impurity 4;Moxifloxacin Impurity 5;Moxifloxacin Impurity 6

Chemical Property of 1-cyclopropyl-6-fluoro-1,4-dihydro-7-((4aR,7aS)-octahydropyrrolo [3,4-b]pyridin-6-yl)-8-Methoxy-4-oxoquinoline-3-carboxylic acid

Chemical Property:

• PSA: 83.80000
• LogP: 3.56630

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclopropyl-6-fluoro-1,4-dihydro-7-((4aR,7aS)-octahydropyrrolo [3,4-b]pyridin-6-yl)-8-Methoxy-4-oxoquinoline-3-carboxylic acid

There total 2 articles about 1-cyclopropyl-6-fluoro-1,4-dihydro-7-((4aR,7aS)-octahydropyrrolo [3,4-b]pyridin-6-yl)-8-Methoxy-4-oxoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(4aS-cis)-1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (O3,O3)bis(acyloxy-O)borate → moxifloxacin hydrochloride (1394029-14-1,1246654-75-0,1346603-25-5)

Guidance literature:

With hydrogenchloride; ethanol; water; at 20 - 25 ℃; for 2h; pH=~ 0.5;

Reference yield: 71.0%

[R,R]-2,8-diazabicyclo[4.3.0]nonane (151213-42-2,158060-81-2,169533-56-6) + 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate (139693-52-0) → moxifloxacin hydrochloride (1394029-14-1,1246654-75-0,1346603-25-5)

Guidance literature:

[R,R]-2,8-diazabicyclo[4.3.0]nonane; 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate; With triethylamine; In acetonitrile; at 15 - 30 ℃; for 8h;

With hydrogenchloride; In methanol; at 15 - 20 ℃; Temperature;

upstream raw materials:

[R,R]-2,8-diazabicyclo[4.3.0]nonane

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate

Refernces

• 1、 -. "AN IMPROVED PROCESS FOR THE PREPARATION OF MOXIFLOXACIN HYDROCHLORIDE". Page/Page column 10-11. . Retrieved 2008/06/13.