LpxC inhibitor 1a

Base Information

Chemical Name:LpxC inhibitor 1a
CAS No.:1289620-49-0
Molecular Formula:C₁₈H₂₁NO₄S
Molecular Weight:347.435
Hs Code.:

Synonyms:LpxC inhibitor 1a

Suppliers and Price of LpxC inhibitor 1a

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Axon Medchem
PF-04753299-PF-4753299|LpxCinhibitor1a 99%
5 mg
$ 99.00

Axon Medchem
PF-04753299-PF-4753299|LpxCinhibitor1a 99%
25 mg
$ 374.00

American Custom Chemicals Corporation
(R)-4-(BIPHENYL-4-YL)-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)BUTANAMIDE 95.00%
5MG
$ 320.10

Total 2 raw suppliers

Chemical Property of LpxC inhibitor 1a

Chemical Property:

PSA：95.34000
LogP:4.51600

Purity/Quality:

99% ^*data from raw suppliers

PF-04753299-PF-4753299|LpxCinhibitor1a 99% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of LpxC inhibitor 1a

There total 8 articles about LpxC inhibitor 1a which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1289626-94-3
(2R)-4-biphenyl-4-yl-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1289620-49-0
(+)-(2R)-4-biphenyl-4-yl-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 - 25 ℃; for 0.25h;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1289626-41-0
(2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanamide

: 1289620-49-0
(+)-(2R)-4-biphenyl-4-yl-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane; methanol / 80 °C

2: hydrogenchloride / 1,4-dioxane / 0.25 h / 20 - 25 °C

With hydrogenchloride; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; 1: Suzuki-Miyaura Coupling;

Reference yield:

: 1354546-62-5
4-biphenyl-4-yl-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1289620-49-0
(+)-(2R)-4-biphenyl-4-yl-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

: 1354546-42-1
(2S)-4-biphenyl-4-yl-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; at 20 ℃; optical yield given as %ee;
DOI:10.1021/jm2014748