11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPIN-8-OL

Base Information

• Chemical Name: 11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPIN-8-OL
• CAS No.: 63687-94-5
• Molecular Formula: C₁₈H₂₀N₄O
• Molecular Weight: 308.383
• Mol file: 63687-94-5.mol

Synonyms:11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPIN-8-OL;5H-DIBENZO[B,E][1,4]DIAZEPIN-8-OL, 11-(4-METHYL-1-PIPERAZINYL)-;GMC 1-116;GMC 1-116 (8-Hydroxy-8-deschloro-clozapine)

Chemical Property of 11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPIN-8-OL

Chemical Property:

• PSA: 51.10000
• LogP: 2.22430

Purity/Quality:

99% ^*data from raw suppliers

GMC 1-116 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPIN-8-OL

There total 4 articles about 11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPIN-8-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) → 11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-ol (63687-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 3 h / Heating

2: EtSH, AlCl₃ / 4 h / Ambient temperature

With aluminium trichloride; ethanethiol; In toluene;

DOI:10.1021/jm9704457

Reference yield:

8-methoxy-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one (93533-11-0) → 11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-ol (63687-94-5)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃, N,N-dimethylaniline / toluene / 3 h / Heating

2: toluene / 3 h / Heating

3: EtSH, AlCl₃ / 4 h / Ambient temperature

With aluminium trichloride; N,N-dimethyl-aniline; ethanethiol; trichlorophosphate; In toluene;

DOI:10.1021/jm9704457

Reference yield:

11-Chloro-8-methoxy-5H-dibenzo[b,e][1,4]diazepine → 11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-ol (63687-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 3 h / Heating

2: EtSH, AlCl₃ / 4 h / Ambient temperature

With aluminium trichloride; ethanethiol; In toluene;

DOI:10.1021/jm9704457

upstream raw materials:

8-methoxy-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

1-methyl-piperazine

8-methoxy-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

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