4-BROMO-2'-CYANOBENZOPHENONE

Base Information

• Chemical Name: 4-BROMO-2'-CYANOBENZOPHENONE
• CAS No.: 746651-85-4
• Molecular Formula: C₁₄H₈BrNO
• Molecular Weight: 286.128
• Hs Code.: 2926909090
• Mol file: 746651-85-4.mol

Synonyms:4-BROMO-2'-CYANOBENZOPHENONE

Chemical Property of 4-BROMO-2'-CYANOBENZOPHENONE

Chemical Property:

• Vapor Pressure: 1.8E-08mmHg at 25°C
• Boiling Point: 455.1°C at 760 mmHg
• Flash Point: 229°C
• PSA: 40.86000
• Density: 1.53g/cm³
• LogP: 3.55178

Purity/Quality:

97% ^*data from raw suppliers

4-bromo-2'-cyanobenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2'-CYANOBENZOPHENONE

There total 5 articles about 4-BROMO-2'-CYANOBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(2-bromophenyl)(4-bromophenyl)methanone (78281-59-1) + copper(l) cyanide → 2-(4-bromobenzoyl)benzonitrile (746651-85-4)

Guidance literature:

In N,N-dimethyl-formamide; at 110 - 120 ℃; for 12h;

DOI:10.1134/S1070428018030065

Reference yield:

(2-bromophenyl)(4-bromophenyl)methanone (78281-59-1) → 2-(4-bromobenzoyl)benzonitrile (746651-85-4)

Guidance literature:

With copper(l) cyanide; In N,N-dimethyl-formamide; at 110 - 120 ℃; for 12h;

DOI:10.1134/S1070428018040085

Reference yield:

o-cyanobromobenzene (2042-37-7) + 4-chlorobenzoyl chloride (586-75-4) → 2-(4-bromobenzoyl)benzonitrile (746651-85-4)

Guidance literature:

o-cyanobromobenzene; With n-butyllithium; In tetrahydrofuran; at -70 ℃; for 0.000133333h;

4-chlorobenzoyl chloride; In tetrahydrofuran; at -70 - 20 ℃; for 0.000133333h; Temperature;

DOI:10.1002/chem.201900743

upstream raw materials:

(2-bromophenyl)(4-bromophenyl)methanone

2-bromobenzoic acid chloride

bromobenzene

o-cyanobromobenzene

Refernces

• 1、 Mochalov,Fedotov,Trofimova,Zefirov. "Reductive Heterocyclization of 2-Cyanobenzophenones by the Action of NaBH4. New Efficient Synthesis of 3-Arylphthalides". . p. 568 - 572. Retrieved 2018/06/11.