Methyl 2-(4-piperidinyloxy)benzoate hydrochloride

Base Information

• Chemical Name: Methyl 2-(4-piperidinyloxy)benzoate hydrochloride
• CAS No.: 936128-84-6
• Molecular Formula: C13H18ClNO3
• Molecular Weight: 271.744
• Hs Code.: 2933399090
• Mol file: 936128-84-6.mol

Synonyms:Methyl 2-(4-piperidinyloxy)benzoate hydrochloride

Chemical Property of Methyl 2-(4-piperidinyloxy)benzoate hydrochloride

Chemical Property:

• PSA: 47.56000
• LogP: 2.73480

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-(4-piperidinyloxy)benzoate hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(4-piperidinyloxy)benzoate hydrochloride

There total 1 articles about Methyl 2-(4-piperidinyloxy)benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(2-methoxycarbonylphenoxy)piperidine-1-carboxylic acid tert-butyl ester → 2-(piperidin-4-yloxy)-benzoic acid methyl ester hydrochloride (936128-84-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

2-(piperidin-4-yloxy)-benzoic acid methyl ester hydrochloride (936128-84-6) + trans-(2-isocyanatocyclopropyl)benzene (35019-96-6,63006-15-5,63009-74-5,79082-68-1) → methyl 2-[(1-{[(1SR,2RS)-2-phenylcyclopropyl]carbamoyl}piperidin-4-yl)oxy]benzoate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2014.01.040

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(piperidin-4-yloxy)-benzoic acid methyl ester hydrochloride (936128-84-6) → 2-(1-methylpiperidin-4-yloxy)benzoic acid methyl ester

Guidance literature:

formaldehyd; 2-(piperidin-4-yloxy)-benzoic acid methyl ester hydrochloride; With triethylamine; In cis-1,2-Dichloroethylene; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In cis-1,2-Dichloroethylene; at 0 - 20 ℃; for 16h; Inert atmosphere;