FGFR4-IN-1

Base Information

• Chemical Name: FGFR4-IN-1
• CAS No.: 1708971-72-5
• Molecular Formula: C24H27N7O5
• Molecular Weight: 493.52
• Mol file: 1708971-72-5.mol

Synonyms:FGFR4-IN-1

Chemical Property of FGFR4-IN-1

Chemical Property:

• Boiling Point: 875.4±65.0 °C(Predicted)
• PKA: 11.39±0.20(Predicted)
• PSA: 149.78000
• Density: 1.41±0.1 g/cm3(Predicted)
• LogP: 1.71148

Purity/Quality:

98% min ^*data from raw suppliers

FGFR4-IN-1 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FGFR4-IN-1

There total 5 articles about FGFR4-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(dimethoxymethyl)-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide → N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide (1708971-72-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2019.04.018

Reference yield:

4-((2-(dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)methyl)morpholin-3-one → N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide (1708971-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

With hydrogenchloride; lithium hexamethyldisilazane; In tetrahydrofuran; water;

DOI:10.1016/j.bmc.2019.04.018

Reference yield:

6-amino-4-fluoronicotinonitrile (1708974-11-1) → N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide (1708971-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2019.04.018

upstream raw materials:

6-amino-4-((2-methoxyethyl)amino)nicotinonitrile

6-amino-4-fluoronicotinonitrile