BOC-4-NITRO-L-PHENYLALANINE

Base Information

• Chemical Name: BOC-4-NITRO-L-PHENYLALANINE
• CAS No.: 336877-68-0
• Molecular Formula: C14H18N2O6
• Molecular Weight: 310.3
• Mol file: 336877-68-0.mol

Synonyms:(S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-NITROPHENYL)PROPANOIC ACID;RARECHEM BK PT 0074;N-TBOC-P-NITRO-L-PHENYLALANINE;N-TERT-BUTOXYCARBONYL-4-NITRO-L-PHENYLALANINE;N-BOC-4-NITRO-L-PHENYLALANINE;N-ALPHA-T-BUTOXYCARBONYL-P-NITRO-L-PHENYLALANINE;N-ALPHA-TERT-BUTYLOXYCARBONYL-4-NITRO-L-PHENYLALANINE;N-ALPHA-T-BUTOXYCARBONYL-(4-NITROPHENYL)-L-ALANINE

Chemical Property of BOC-4-NITRO-L-PHENYLALANINE

Chemical Property:

• Vapor Pressure: 2.01E-10mmHg at 25°C
• Boiling Point: 490.2°C at 760 mmHg
• Flash Point: 250.2°C
• PSA: 121.45000
• Density: 1.32g/cm³
• LogP: 3.02930
• Storage Temp.: −20°C

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BOC-4-NITRO-L-PHENYLALANINE

There total 2 articles about BOC-4-NITRO-L-PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-2-(4-nitrophenyl)acetic acid (336877-66-8) → L-N-(tert-butoxycarbonyl)-4-nitrophenylglycine (336877-68-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane;

Reference yield:

(S)-2-phenylglycine (2935-35-5) → L-N-(tert-butoxycarbonyl)-4-nitrophenylglycine (336877-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / HNO₃ conc.; H₂SO₄ conc. / 0.5 h / 0 - 5 °C

2: 48 percent / aq. NaOH / dioxane

With sodium hydroxide; sulfuric acid; nitric acid; In 1,4-dioxane;

Reference yield: 68.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + Boc-Arg(Tos)-OH (13836-37-8) + L-N-(tert-butoxycarbonyl)-4-nitrophenylglycine (336877-68-0) → H-Arg-Phg(4-NO2)-Leu-Pro-Thr-OH (336877-88-4)

Guidance literature:

Multistep reaction;

upstream raw materials:

di-tert-butyl dicarbonate

2-amino-2-(4-nitrophenyl)acetic acid

(S)-2-phenylglycine

Downstream raw materials:

L-N-(tert-butoxycarbonyl)-4-(N,N-dimethylamino)phenylglycine

H-Arg-Phg(4-NO₂)-Leu-Pro-Thr-OH

Refernces