6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine
• CAS No.: 83472-62-2
• Molecular Formula: C₆H₃BrClN₃
• Molecular Weight: 232.467
• Hs Code.: 2933990090

Synonyms:6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine;6-BroMo-7-chloro-3H-iMida...

Chemical Property of 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine

Chemical Property:

• PSA: 41.57000
• LogP: 2.37380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine

There total 8 articles about 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-3H-imidazo[4,5-b]pyridine 4-oxide → 6-bromo-5-chloro-3H-imidazo[4,5-b]pyridine + 6-bromo-7-chloro-3H-imidazo[4,5-b]pyridine (83472-62-2)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 0.166667h; Overall yield = 40 %; Overall yield = 1.43 g; Microwave irradiation;

DOI:10.1021/acs.joc.6b00406

Reference yield:

6-Bromo-1-trimethylsilanyl-1H-imidazo[4,5-b]pyridine 4-oxide (1071000-23-1) → 6-bromo-7-chloro-3H-imidazo[4,5-b]pyridine (83472-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1: SnCl₄ / acetonitrile / 18 h / Ambient temperature

2: 65 percent / POCl3, 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose / Molecular sieve 4A / CHCl3 / 24 h / 30 - 33 °C

3: 35 mg / Conc_. HCl / ethanol / 4 h

With hydrogenchloride; tin(IV) chloride; 1,2,3,5-tetraacetylribose; trichlorophosphate; 4 A molecular sieve; In ethanol; chloroform; acetonitrile;

DOI:10.1002/jhet.5570190313

Reference yield:

6-Bromo-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-imidazo<4,5-b>pyridine 4-Oxide (83472-69-9) → 6-bromo-7-chloro-3H-imidazo[4,5-b]pyridine (83472-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / POCl3, 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose / Molecular sieve 4A / CHCl3 / 24 h / 30 - 33 °C

2: 35 mg / Conc_. HCl / ethanol / 4 h

With hydrogenchloride; 1,2,3,5-tetraacetylribose; trichlorophosphate; 4 A molecular sieve; In ethanol; chloroform;

DOI:10.1002/jhet.5570190313

upstream raw materials:

6-Bromo-7-chloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-imidazo<4,5-b>pyridine

6-Bromo-1-trimethylsilanyl-1H-imidazo[4,5-b]pyridine 4-oxide

6-Bromo-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-imidazo<4,5-b>pyridine 4-Oxide

6-bromo-3H-imidazo[4,5-b]pyridine

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