3,5-DIISOPROPYLBENZALDEHYDE

Base Information

• Chemical Name: 3,5-DIISOPROPYLBENZALDEHYDE
• CAS No.: 112538-48-4
• Molecular Formula: C13H18O
• Molecular Weight: 190.285
• Hs Code.: 2912299000
• Mol file: 112538-48-4.mol

Synonyms:3,5-DIISOPROPYLBENZALDEHYDE

Chemical Property of 3,5-DIISOPROPYLBENZALDEHYDE

Chemical Property:

• Boiling Point: 141-146 °C(Press: 9 Torr)
• PSA: 17.07000
• Density: 0.972 g/cm3(Temp: 18 °C)
• LogP: 3.74590
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Diisopropylbenzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-DIISOPROPYLBENZALDEHYDE

There total 3 articles about 3,5-DIISOPROPYLBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(3,5-diisopropenylphenyl)-1,3-dioxolane → 3,5-diisopropyl benzaldehyde (112538-48-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 10 ℃; for 3h; under 775.743 Torr; Inert atmosphere;

Reference yield:

1-bromo-3,5-bis(propan-2-yl)benzene (23058-81-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3,5-diisopropyl benzaldehyde (112538-48-4)

Guidance literature:

1-bromo-3,5-bis(propan-2-yl)benzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - -10 ℃; Further stages.;

DOI:10.1021/jo7026917

Reference yield:

2-(3,5-dibromophenyl)-1,3-dioxolane (773094-77-2) → 3,5-diisopropyl benzaldehyde (112538-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 12 h / 90 °C / Sealed tube; Inert atmosphere

2: hydrogen; palladium on activated charcoal / ethyl acetate / 3 h / 10 °C / 775.74 Torr / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; sodium carbonate; In 1,2-dimethoxyethane; water; ethyl acetate;

upstream raw materials:

1-bromo-3,5-bis(propan-2-yl)benzene

N,N-dimethyl-formamide

2-(3,5-dibromophenyl)-1,3-dioxolane

Downstream raw materials:

9-(3,5-diisopropylbenzylidene)-9H-fluorene

(3,5-diisopropylphenyl)(9-H-fluoren-9-yl)methanol

Refernces

• 1、 Casarini, Daniele,Lunazzi, Lodovico,Mazzanti, Andrea. "Correlated rotations in benzylfluorene derivatives: Structure, conformation, and stereodynamics". . p. 2811 - 2818. Retrieved 2008/09/19.