JNK Inhibitor VIII

Base Information

Chemical Name:JNK Inhibitor VIII
CAS No.:894804-07-0
Molecular Formula:C₁₈H₂₀N₄O₄
Molecular Weight:356.381
Hs Code.:
ChEMBL ID:CHEMBL210618
DSSTox Substance ID:DTXSID20469650
Pharos Ligand ID:GPD8Z6HKRT18
Wikidata:Q82297468
Mol file:894804-07-0.mol

Synonyms:JNK Inhibitor VIII;894804-07-0;TCS JNK 6o;N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide;aminopyridine deriv. 2;TCS JNK 6o(JNK Inhibitor VIII);N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide;Kinome_3020;JNK inhibitor compound 6o;SCHEMBL157014;CHEMBL210618;GTPL5998;Aminopyridine-Based Inhibitor 6o;BDBM15908;DTXSID20469650;HMS3229K06;EX-A4018;s7794;AKOS024457488;CCG-206859;NCGC00387087-01;AS-82214;HY-107598;CS-0028935;D80453

Suppliers and Price of JNK Inhibitor VIII

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
TCS JNK 6o
10mg
$ 480.00

TRC
JNKInhibitorVIII
25mg
$ 550.00

TRC
JNKInhibitorVIII
5mg
$ 125.00

Tocris
TCSJNK6o ≥98%(HPLC)
10
$ 233.00

Tocris
TCSJNK6o ≥98%(HPLC)
50
$ 990.00

DC Chemicals
TCSJNK6o(JNKInhibitorVIII)
003
$ 2500.00

DC Chemicals
TCSJNK6o(JNKInhibitorVIII)
002
$ 1350.00

DC Chemicals
TCSJNK6o(JNKInhibitorVIII)
001
$ 700.00

ChemScene
JNKInhibitorVIII 99.56%
5mg
$ 480.00

ChemScene
JNKInhibitorVIII 99.56%
1mg
$ 160.00

Total 13 raw suppliers

Chemical Property of JNK Inhibitor VIII

Chemical Property:

PSA：122.72000
LogP:2.13568
Solubility.:Soluble in DMSO
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:356.14845513
Heavy Atom Count:26
Complexity:509

Purity/Quality:

99%, ^*data from raw suppliers

TCS JNK 6o ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=C(C(=CC(=N1)NC(=O)CC2=C(C=CC(=C2)OC)OC)N)C#N
Description c-Jun amino terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. They have been implicated in neurodegeneration, rheumatoid arthritis, inflammation, cancer, and diabetes. JNK1 and JNK2 are widely expressed throughout the body whereas JNK3 is predominantly distributed in the brain. JNK Inhibitor VIII is an aminopyridine compound that inhibits JNK1, JNK2, and JNK3 with Ki values of 2, 4, and 52 nM, respectively. It has been reported to inhibit the phosphorylation of the JNK substrate c-Jun in HepG2 cells (EC50 = 920 nM) without affecting the expression of IL-6, IL-8, or COX-2.
Uses JNK Inhibitor VIII is an inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release.

Technology Process of JNK Inhibitor VIII

There total 1 articles about JNK Inhibitor VIII which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%