4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine

Base Information

• Chemical Name: 4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine
• CAS No.: 1072027-36-1
• Molecular Formula: C₁₅H₂₀BrN₅O₂
• Molecular Weight: 382.26
• Mol file: 1072027-36-1.mol

Synonyms:4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine;tert-butyl 4-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxylate

Chemical Property of 4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine

Chemical Property:

• PKA: 12.19±0.50(Predicted)
• PSA: 74.35000
• Density: 1.498±0.06 g/cm3(Predicted)
• LogP: 2.78040
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine is used as a reactant in the preparation of 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives as Akt inhibitors with antiproliferative effects.

Technology Process of 4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine

There total 2 articles about 4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (22276-95-5) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester (1072027-36-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 80 ℃; for 2h; Microwave irradiation;

Reference yield: 48.0%

→ 4-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester (1072027-36-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 110 ℃; for 16h;

Reference yield: 99.2%

4-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester (1072027-36-1) → 5-bromo-4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine dihydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 2h;

upstream raw materials:

5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

1-t-Butoxycarbonylpiperazine