Paprotrain

Base Information

Chemical Name:Paprotrain
CAS No.:57046-73-8
Molecular Formula:C16H11N3
Molecular Weight:245.27864
Hs Code.:

Synonyms:Paprotrain;(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile

Suppliers and Price of Paprotrain

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Paprotrain
1mg
$ 325.00

TRC
Paprotrain
25mg
$ 120.00

TRC
Paprotrain
10mg
$ 60.00

Tocris
Paprotrain ≥99%(HPLC)
50
$ 342.00

Tocris
Paprotrain ≥99%(HPLC)
10
$ 81.00

CSNpharm
Paprotrain
25mg
$ 130.00

CSNpharm
Paprotrain
50mg
$ 200.00

ChemScene
Paprotrain 99.54%
100mg
$ 408.00

ChemScene
Paprotrain 99.54%
50mg
$ 228.00

ChemScene
Paprotrain 99.54%
25mg
$ 144.00

Total 8 raw suppliers

Chemical Property of Paprotrain

Chemical Property:

Melting Point:202℃
PSA：52.47000
LogP:3.62708
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Paprotrain ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Mitotic kinesin-like protein 2 (MKLP-2) is an N-terminal motor from the kinesin-6 family that is essential for normal cleavage furrow ingression and cytokinesis. Its activity mediates the relocation of the chromosome passenger proteins Aurora B kinase and survivin from the centromeres to the central spindle in anaphase cells in order to facilitate cytokinesis, avoiding the generation of binucleated cells. Paprotrain, PAssenger PROteins TRAnsport INhibitor, is the first known inhibitor of MKLP-2. It is a cell-permeable, reversible inhibitor uncompetitive with ATP (Ki = 3.4 μM) and noncompetitive with microtubules (Ki = 1.6 μM), demonstrating ATPase inhibition of basal and microtubule-stimulated activities with IC50 values of 1.35 and 0.83 μM, respectively. Paprotrain does not inhibit twelve additional kinesins, including the closely related kinesin-6 motors MKLP-1 and MPP1. Incubation with 10-50 μM paprotrain results in binucleated cells, perturbing relocation of Aurora B kinase and survivin without affecting microtubule polymerization.
Uses Paprotrain is a cell-permeable inhibitor of the kinesin-6 family member KIF20A (MKLP-2).

Technology Process of Paprotrain

There total 2 articles about Paprotrain which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%