2,4-Dibromobenzeneacetic acid

Base Information

• Chemical Name: 2,4-Dibromobenzeneacetic acid
• CAS No.: 98434-44-7
• Molecular Formula: C8H6Br2O2
• Molecular Weight: 293.942
• Hs Code.: 2916399090
• Mol file: 98434-44-7.mol

Synonyms:2,4-Dibromobenzeneacetic acid

Chemical Property of 2,4-Dibromobenzeneacetic acid

Chemical Property:

• Melting Point: 141-142℃
• PSA: 37.30000
• Density: 1.969
• LogP: 2.83870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2,4-DibromobenzeneaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dibromobenzeneacetic acid

There total 6 articles about 2,4-Dibromobenzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,4-dibromophenyl)acetonitrile (66246-16-0) → (2,4-dibromophenyl)acetic acid (98434-44-7)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 3h; Heating;

DOI:10.1021/jm0604528

Reference yield:

2,4-dibromobenzyl methanesulfonate → (2,4-dibromophenyl)acetic acid (98434-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide; H₂O / 3.5 h / 20 °C

2: 3.1 g / KOH / ethanol; H₂O / 3 h / Heating

With potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm0604528

Reference yield:

2,4-dibromobenzaldehyde (5629-98-1) → (2,4-dibromophenyl)acetic acid (98434-44-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 14.0 g / NaBH₄ / tetrahydrofuran / 3.83 h / 0 - 20 °C

2: Et₃N / tetrahydrofuran / 1.83 h / 0 - 20 °C

3: dimethylformamide; H₂O / 3.5 h / 20 °C

4: 3.1 g / KOH / ethanol; H₂O / 3 h / Heating

With potassium hydroxide; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm0604528

upstream raw materials:

2-(2,4-dibromophenyl)acetonitrile

2,4-dibromobenzaldehyde

2,4-dibromo-aniline

(2,4-dibromophenyl)methanol

Downstream raw materials:

2,4-dibromophenethyl alcohol

Refernces

• 1、 Zhidkov, Maxim E.,Baranova, Olga V.,Balaneva, Nadezhda N.,Fedorov, Sergey N.,Radchenko, Oleg S.,Dubovitskii, Sergey V.. "The first syntheses of 3-bromofascaplysin, 10-bromofascaplysin and 3,10-dibromofascaplysin-marine alkaloids from Fascaplysinopsis reticulata and Didemnum sp. by application of a simple and effective approach to the pyrido[1,2-a:3,4-b′]diindole system". . p. 7998 - 8000. Retrieved 2008/03/14.