PRAMIRACETAM SULFATE

Base Information

• Chemical Name: PRAMIRACETAM SULFATE
• CAS No.: 72869-16-0
• Molecular Formula: C₁₄H₂₇N₃O₂*H₂O₄S
• Molecular Weight: 367.467
• Mol file: 72869-16-0.mol

Synonyms:N-(2-(Diisopropylamino)ethyl)-2-oxo-1-pyrrolidineacetamide sulfate (1:1);N-(2-(Bis(1-methylethyl)amino)ethyl)-2-oxo-1-pyrrolidineacetamide sulfate;CI-879 sulfate;CI 879;68497-62-1;1-Pyrrolidineacetamide,N-[2-[bis(1-methylethyl) amino]ethyl]-2-oxo-,sulfate (1:1);Amacetam sulfate;Pramiracetamum [INN-Latin];N-[2-(dipropan-2-ylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide;Pramiracetam sulfate [USAN];N-[2-(dipropan-2-ylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide; sulfuric acid;1-Pyrrolidineacetamide,N-[2-[bis(1-methyl- ethyl)amino]ethyl]-2-oxo-,sulfate (1:1);Pramiracetam?Sulfate;

Chemical Property of PRAMIRACETAM SULFATE

Chemical Property:

• Boiling Point: 461 °C at 760 mmHg
• Flash Point: 232.6 °C
• PSA: 135.63000
• LogP: 1.60060

Purity/Quality:

99% ^*data from raw suppliers

PramiracetamSulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Pramiracetam sulfate, together with aniracetam are two nootropics of the piracetam family introduced in 1993 for the treatment of attention and memory disorders resulting from degenerative or vascular disorders in the elderly. In patients with mild to moderate primary degenerative dementia, treatment with 75-300 mg/day of pramiracetam reduced depression,anxiety, sleep disturbance, and hostility with no observable adverse reactions. Significant improvement of performance on measures of memory, especially delayed recall, have been observed for pramiracetam treated patients with brain injury.
• Uses: Pramiracetam Sulfate is a nootropic and a cognition activator drug. It also increases the rate of learning of complex visual discrimination problems in young, normal rhesus monkeys. Cognition adjuvant.

Technology Process of PRAMIRACETAM SULFATE

There total 2 articles about PRAMIRACETAM SULFATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.83%

pramiracetam (68497-62-1) → Pramiracetam sulfate (72869-16-0)

Guidance literature:

With sulfuric acid; In acetonitrile; at 0 - 5 ℃;

Reference yield:

N',N'-diisopropyl-ethane-1,2-diamine (121-05-1) → Pramiracetam sulfate (72869-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1.67 h / 0 - 15 °C

2.1: sodium methylate / toluene / 3 h / 105 - 108 °C

2.2: 60 - 70 °C

3.1: sulfuric acid / acetonitrile / 0 - 5 °C

With sulfuric acid; sodium methylate; In tetrahydrofuran; toluene; acetonitrile;

upstream raw materials:

N',N'-diisopropyl-ethane-1,2-diamine

pramiracetam

Refernces