2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide

Base Information

• Chemical Name: 2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide
• CAS No.: 1123163-33-6
• Molecular Formula: C₉H₅F₄N₃O
• Molecular Weight: 247.152
• Hs Code.: 2933990090
• Mol file: 1123163-33-6.mol

Synonyms:2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide

Chemical Property of 2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide

Chemical Property:

• PKA: 0.94±0.46(Predicted)
• PSA: 49.89000
• Density: 1.59±0.1 g/cm3(Predicted)
• LogP: 2.62370
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2,2,2-Trifluoro-N-(6-fluoro-imidazo[1,2-a]pyridin-2-yl)-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide

There total 4 articles about 2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(E)-2-(5-Fluoro-2-(tosylimino)pyridin-1(2H)-yl)acetamide (1352624-97-5) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(6-fluoroimidazo[1,2-a]pyridin-2-yl)acetamide (1123163-33-6)

Guidance literature:

In dichloromethane; for 3h; Reflux;

Reference yield:

2-(5-fluoro-2-(tosylimino)pyridin-1(2H)-yl)acetamide (1123163-32-5) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(6-fluoroimidazo[1,2-a]pyridin-2-yl)acetamide (1123163-33-6)

Guidance literature:

2-(5-fluoro-2-(tosylimino)pyridin-1(2H)-yl)acetamide; trifluoroacetic anhydride; In dichloromethane; at 18 - 25 ℃; for 0.5 - 1h;

With sodium hydrogencarbonate; In water; ethyl acetate; Product distribution / selectivity;

Reference yield:

2-amino-5-fluoropyridine (21717-96-4) → 2,2,2-trifluoro-N-(6-fluoroimidazo[1,2-a]pyridin-2-yl)acetamide (1123163-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 18 h / 90 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 38 h / 20 °C

3: dichloromethane / 3 h / Reflux

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-(5-fluoro-2-(tosylimino)pyridin-1(2H)-yl)acetamide

trifluoroacetic anhydride

(E)-2-(5-Fluoro-2-(tosylimino)pyridin-1(2H)-yl)acetamide

2-amino-5-fluoropyridine

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