benzyl 10-iodo-2-oxo-1-oxa-6-azaspiro[4.5]decane-6-carboxylate

Base Information

Chemical Name:benzyl 10-iodo-2-oxo-1-oxa-6-azaspiro[4.5]decane-6-carboxylate
CAS No.:157982-71-3
Molecular Formula:C16H18INO4
Molecular Weight:415.22289
Hs Code.:
Mol file:157982-71-3.mol

Synonyms:1-Oxa-6-azaspiro[4.5]decane-6-carboxylic acid, 10-iodo-2-oxo-, phenylMethyl ester

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Chemical Property of benzyl 10-iodo-2-oxo-1-oxa-6-azaspiro[4.5]decane-6-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:550.156°C at 760 mmHg
Flash Point:286.524°C
Density:1.659g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of benzyl 10-iodo-2-oxo-1-oxa-6-azaspiro[4.5]decane-6-carboxylate

There total 7 articles about benzyl 10-iodo-2-oxo-1-oxa-6-azaspiro[4.5]decane-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 157982-68-8
6-(2-Carboxy-ethyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 157982-71-3,215106-50-6
10-Iodo-2-oxo-1-oxa-6-aza-spiro[4.5]decane-6-carboxylic acid benzyl ester

Guidance literature:: With N-iodo-succinimide; sodium hydrogencarbonate; In dichloromethane; for 1h;
DOI:10.1016/S0040-4039(00)73161-3

Reference yield:

: 129605-87-4
tert-Butyl N-(benzyloxycarbonyl)-2(RS)-allylpipecolate

: 157982-71-3,215106-50-6
10-Iodo-2-oxo-1-oxa-6-aza-spiro[4.5]decane-6-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / B₂H₆, H₂O₂ / 4.5 h

2: 91 percent / PDC / dimethylformamide / 22 h / Ambient temperature

3: 90 percent / diethyl ether

4: 100 percent / trifluoroacetic acid / 3 h / Ambient temperature

5: 84 percent / diphenylphosprazidate, triethylamine / toluene / 90 °C

6: 78 percent / 10 N NaOH / methanol

7: 75 percent / NIS, sodium bicarbonate / CH₂Cl₂ / 1 h

With sodium hydroxide; N-iodo-succinimide; dipyridinium dichromate; diphenyl phosphoryl azide; dihydrogen peroxide; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; diborane; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)73161-3

Reference yield:

: 157982-67-7
methyl 3-(1'-benzyloxycarbonyl-1',4',5',6'-tetrahydropyridine-2'-yl)-propanoate

: 157982-71-3,215106-50-6
10-Iodo-2-oxo-1-oxa-6-aza-spiro[4.5]decane-6-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / 10 N NaOH / methanol

2: 75 percent / NIS, sodium bicarbonate / CH₂Cl₂ / 1 h

With sodium hydroxide; N-iodo-succinimide; sodium hydrogencarbonate; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)73161-3