CYCLOBUTYL 4-TRIFLUOROMETHYLPHENYL KETONE

Base Information

• Chemical Name: CYCLOBUTYL 4-TRIFLUOROMETHYLPHENYL KETONE
• CAS No.: 53342-40-8
• Molecular Formula: C12H11F3O
• Molecular Weight: 228.21
• Hs Code.: 2914700090
• Mol file: 53342-40-8.mol

Synonyms:CYCLOBUTYL 4-TRIFLUOROMETHYLPHENYL KETONE

Chemical Property of CYCLOBUTYL 4-TRIFLUOROMETHYLPHENYL KETONE

Chemical Property:

• Vapor Pressure: 0.00366mmHg at 25°C
• Boiling Point: 281°C at 760 mmHg
• Flash Point: 131.7°C
• PSA: 17.07000
• Density: 1.257g/cm³
• LogP: 3.68820

Purity/Quality:

97% ^*data from raw suppliers

Cyclobutyl4-trifluoromethylphenylketone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOBUTYL 4-TRIFLUOROMETHYLPHENYL KETONE

There total 2 articles about CYCLOBUTYL 4-TRIFLUOROMETHYLPHENYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C10H11NOS + C7H4F3(1-)*C5H9O2(1-)*Zn(2+) → Cyclobutyl-(4-trifluoromethyl-phenyl)-methanone (53342-40-8)

Guidance literature:

With 4,4'-di-tert-butyl-2,2'-bipyridine; cobalt(II) chloride; In tetrahydrofuran; at 25 ℃; for 4h;

DOI:10.1039/c9sc01817d

Reference yield:

Cyclobutanecarboxylic acid (3721-95-7) → Cyclobutyl-(4-trifluoromethyl-phenyl)-methanone (53342-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine / acetonitrile / 3 h / Reflux

2: cobalt(II) chloride; 4,4'-di-tert-butyl-2,2'-bipyridine / tetrahydrofuran / 4 h / 25 °C

With triphenylphosphine; 4,4'-di-tert-butyl-2,2'-bipyridine; cobalt(II) chloride; In tetrahydrofuran; acetonitrile;

DOI:10.1039/c9sc01817d

upstream raw materials:

Cyclobutanecarboxylic acid