(2S,4S)-4-(aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S,4S)-4-(aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
CAS No.:132622-95-8
Molecular Formula:C11H20N2O4
Molecular Weight:244.291
Hs Code.:
DSSTox Substance ID:DTXSID40564616
Wikidata:Q72439609
Mol file:132622-95-8.mol

Synonyms:132622-95-8;(2S,4S)-4-(aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;(2S,4S)-4-(aminomethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;SCHEMBL9730895;DTXSID40564616;(2S,4S)-4-(aminomethyl)-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid;VWFCKAANOBELKO-YUMQZZPRSA-N;CS-0184627;(4S)-1-(tert-Butoxycarbonyl)-4-(aminomethyl)-L-proline;(4S)-4-(Aminomethyl)-1-(tert-butoxycarbonyl)-L-proline

Suppliers and Price of (2S,4S)-4-(aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (2S,4S)-4-(aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Chemical Property:

PSA：92.86000
Density:1.197
LogP:1.29350
XLogP3:-2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:244.14230712
Heavy Atom Count:17
Complexity:311

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(CC1C(=O)O)CN
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(=O)O)CN

Technology Process of (2S,4S)-4-(aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

There total 6 articles about (2S,4S)-4-(aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 132622-95-8
(4R)-1-(tert-butoxycarbonyl)-4-(aminomethyl)-L-proline

Guidance literature:

Reference yield: 67.0%

: 132622-94-7
(4R)-1-(tert-butoxycarbonyl)-4-cyano-L-proline benzyl ester

: 132622-95-8
(4R)-1-(tert-butoxycarbonyl)-4-(aminomethyl)-L-proline

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; at 22 ℃; under 23271.7 Torr;
DOI:10.1021/jo00009a016

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 132622-95-8
(4R)-1-(tert-butoxycarbonyl)-4-(aminomethyl)-L-proline

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / N,N-diisopropylethylamine / dioxane / 0.5 h

2: pyridine / 22 °C

3: 52 percent / dimethylsulfoxide / 55 °C

4: 67 percent / H₂ / 10percent Pd/C / H₂O; ethanol / 22 °C / 23271.7 Torr

With pyridine; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jo00009a016