tert-Butyl 4-(diphenylamino)[1,4'-bipiperidine]-1'-carboxylate

Base Information

Chemical Name:tert-Butyl 4-(diphenylamino)[1,4'-bipiperidine]-1'-carboxylate
CAS No.:470690-00-7
Molecular Formula:C27H37N3O2
Molecular Weight:435.6
Hs Code.:
DSSTox Substance ID:DTXSID90701731
Mol file:470690-00-7.mol

Synonyms:SCHEMBL3841257;DTXSID90701731;CCOICZDOKLQTOX-UHFFFAOYSA-N;470690-00-7;tert-Butyl 4-(diphenylamino)[1,4'-bipiperidine]-1'-carboxylate;4-Diphenylamino-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

Suppliers and Price of tert-Butyl 4-(diphenylamino)[1,4'-bipiperidine]-1'-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TERT-BUTYL-4-(4-(DIPHENYLAMINO)PIPERIDIN-1-YL)PIPERIDINE-1-CARBOXYLATE 95.00%
5MG
$ 502.36

Total 0 raw suppliers

Chemical Property of tert-Butyl 4-(diphenylamino)[1,4'-bipiperidine]-1'-carboxylate

Chemical Property:

PSA：36.02000
LogP:5.56440
XLogP3:5.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:435.28857743
Heavy Atom Count:32
Complexity:558

Purity/Quality:: TERT-BUTYL-4-(4-(DIPHENYLAMINO)PIPERIDIN-1-YL)PIPERIDINE-1-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)N2CCC(CC2)N(C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of tert-Butyl 4-(diphenylamino)[1,4'-bipiperidine]-1'-carboxylate

There total 5 articles about tert-Butyl 4-(diphenylamino)[1,4'-bipiperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 84359-50-2
N,N-diphenylpiperidine-4-amine

: 470690-00-7
4-diphenylamino-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 65 ℃; for 4h;
DOI:10.1021/jm031046g

Reference yield:

: 125541-22-2
1-(tert-butoxycarbonyl)-4-phenylaminopiperidine

: 470690-00-7
4-diphenylamino-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / Pd(OAc)2; BINAP; t-BuOK / tetrahydrofuran; toluene / 16 h / 110 °C

2: aq. TFA / 3 h / 25 °C

3: 1.06 g / (CH₃COO)3NaBH; AcOH / 1,2-dichloro-ethane / 4 h / 65 °C

With palladium diacetate; potassium tert-butylate; sodium tris(acetoxy)borohydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; trifluoroacetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jm031046g

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 470690-00-7
4-diphenylamino-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / (CH₃COO)3NaBH; AcOH / 1,2-dichloro-ethane / 16 h

2: 52 percent / Pd(OAc)2; BINAP; t-BuOK / tetrahydrofuran; toluene / 16 h / 110 °C

3: aq. TFA / 3 h / 25 °C

4: 1.06 g / (CH₃COO)3NaBH; AcOH / 1,2-dichloro-ethane / 4 h / 65 °C

With palladium diacetate; potassium tert-butylate; sodium tris(acetoxy)borohydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; trifluoroacetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jm031046g