2-(Pyrrolidin-1-ylcarbonyl)piperidine

Base Information

• Chemical Name: 2-(Pyrrolidin-1-ylcarbonyl)piperidine
• CAS No.: 130605-98-0
• Molecular Formula: C10H18N2O
• Molecular Weight: 182.266
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20383327
• Mol file: 130605-98-0.mol

Synonyms:130605-98-0;2-(pyrrolidin-1-ylcarbonyl)piperidine;piperidin-2-yl(pyrrolidin-1-yl)methanone;Piperidin-2-yl-pyrrolidin-1-yl-methanone;2-(pyrrolidine-1-carbonyl)piperidine;1-(2-piperidinylcarbonyl)-pyrrolidine;SCHEMBL6586024;DTXSID20383327;STK500813;AKOS000165622;AKOS016343937;piperidin-2-ylpyrrolidin-1-ylmethanone;SB41419;LS-02128;BB 0253768;CS-0444246;FT-0679065;C77849;EN300-145170

Chemical Property of 2-(Pyrrolidin-1-ylcarbonyl)piperidine

Chemical Property:

• Vapor Pressure: 0.000121mmHg at 25°C
• Boiling Point: 335.3°C at 760 mmHg
• Flash Point: 156.6°C
• PSA: 32.34000
• Density: 1.074g/cm³
• LogP: 1.01760
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 182.141913202
• Heavy Atom Count: 13
• Complexity: 187

Purity/Quality:

97% ^*data from raw suppliers

2-(Pyrrolidin-1-ylcarbonyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)C(=O)N2CCCC2

Technology Process of 2-(Pyrrolidin-1-ylcarbonyl)piperidine

There total 4 articles about 2-(Pyrrolidin-1-ylcarbonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H26N2O3 → 1-(2-piperidinylcarbonyl)pyrrolidine (130605-98-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2008.03.078

Reference yield:

(+/-)-[(N-ethoxycarbonyl)piperidine]-2-carboxylic acid (130497-14-2) → 1-(2-piperidinylcarbonyl)pyrrolidine (130605-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 24 h / Ambient temperature

2: CH₂Cl₂ / -5 °C

With thionyl chloride; In dichloromethane;

DOI:10.1021/jm00105a061

Reference yield:

pipecolic Acid (4043-87-2,83680-83-5) → 1-(2-piperidinylcarbonyl)pyrrolidine (130605-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / H₂O / 0 °C

2: SOCl₂ / CH₂Cl₂ / 24 h / Ambient temperature

3: CH₂Cl₂ / -5 °C

With sodium hydroxide; thionyl chloride; In dichloromethane; water;

DOI:10.1021/jm00105a061

upstream raw materials:

pyrrolidine

piperidine-2-carbonyl chloride

(+/-)-[(N-ethoxycarbonyl)piperidine]-2-carboxylic acid

pipecolic Acid

Downstream raw materials:

2-(4-Cyclohexyl-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone

ZT 52656A

1-(2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-2-(2-trifluoromethyl-phenyl)-ethanone

[3H]-BRL 52537