Ethyl 4-chloro-7-methylquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 4-chloro-7-methylquinoline-3-carboxylate
CAS No.:50593-19-6
Molecular Formula:C13H12ClNO2
Molecular Weight:249.69288
Hs Code.:
DSSTox Substance ID:DTXSID60481351
Wikidata:Q82316706
Mol file:50593-19-6.mol

Synonyms:ETHYL 4-CHLORO-7-METHYLQUINOLINE-3-CARBOXYLATE;50593-19-6;SCHEMBL12426321;DTXSID60481351;AKOS005146273;EN300-154640

Suppliers and Price of Ethyl 4-chloro-7-methylquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Ethyl 4-chloro-7-methylquinoline-3-carboxylate

Chemical Property:

Vapor Pressure:5.77E-05mmHg at 25°C
Boiling Point:346.4°C at 760 mmHg
Flash Point:163.3°C
PSA：39.19000
Density:1.252g/cm³
LogP:3.37330
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:249.0556563
Heavy Atom Count:17
Complexity:285

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C2C=C(C=CC2=C1Cl)C

Technology Process of Ethyl 4-chloro-7-methylquinoline-3-carboxylate

There total 5 articles about Ethyl 4-chloro-7-methylquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41460-18-8
ethyl 4-hydroxy-7-methylquinoline-3-carboxylate

: 50593-19-6
ethyl 4-chloro-7-methylquinoline-3-carboxylate

Guidance literature:: With trichlorophosphate; In toluene; for 30h; Yield given; Heating;
DOI:10.1248/cpb.30.3517

Reference yield:

: 19056-83-8
diethyl 2-{[(3-methylphenyl)amino]methylene}propane-1,3-dioate

: 50593-19-6
ethyl 4-chloro-7-methylquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: various solvent(s) / 0.5 h / 250 °C

2: POCl₃ / 5 h / Heating

With trichlorophosphate; In various solvent(s);
DOI:10.1016/S0014-827X(98)00072-X

Reference yield:

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 50593-19-6
ethyl 4-chloro-7-methylquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2 h / 110 - 115 °C

2: various solvent(s) / 0.5 h / 250 °C

3: POCl₃ / 5 h / Heating

With trichlorophosphate; In various solvent(s);
DOI:10.1016/S0014-827X(98)00072-X