(S)-BoroLeu-(-)-Pinanediol-CF3COOH

Base Information

• Chemical Name: (S)-BoroLeu-(-)-Pinanediol-CF3COOH
• CAS No.: 477254-69-6
• Molecular Formula: C17H29BF3NO4
• Molecular Weight: 379.2226696
• Mol file: 477254-69-6.mol

Synonyms:(S)-BoroLeu-(-)-Pinanediol-CF3COOH;4,6-Methano-1,3,2-benzodioxaborole-2-methanamine, hexahydro-3a,5,5-trimethyl-a-(2-methylpropyl)-, (aS,3aS,4S,6S,7aR)-, trifluoroacetate

Chemical Property of (S)-BoroLeu-(-)-Pinanediol-CF3COOH

Chemical Property:

• PSA: 81.78000
• LogP: 4.38080

Purity/Quality:

99% ^*data from raw suppliers

(S)-BoroLeu-(+)-pinanediol-trifluoroacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-BoroLeu-(-)-Pinanediol-CF3COOH

There total 1 articles about (S)-BoroLeu-(-)-Pinanediol-CF3COOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(1S)-(S)-pinanediol 1-bis(trimethylsilyl)amino-3-methylbutane-1-boronate (1135491-84-7) + trifluoroacetic acid (76-05-1) + 1,1,1-trimethyl-N-{(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}-N-(trimethylsilyl)silanamine (514820-48-5) → (aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate (1310383-72-2,179324-87-9) + (1S)-(S)-pinanediol 1-ammonium trifluoroacetate-3-methylbutane-1-boronate (477254-69-6,1310383-72-2,179324-87-9)

Guidance literature:

In di-isopropyl ether; methyl cyclohexane; at -10 - -5 ℃; for 9h; Industry scale;

Reference yield:

(aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate (1310383-72-2,179324-87-9) + (1S)-(S)-pinanediol 1-ammonium trifluoroacetate-3-methylbutane-1-boronate (477254-69-6,1310383-72-2,179324-87-9) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (1S,2S,3R,5S)-pinanediol N-BOC-L-phenylalanine-L-leucine boronate (1187479-72-6) + (1S,2S,3R,5S)-pinanediol N-BOC-L-phenylalanine-L-leucine boronate

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0.7 - 2.5 ℃; for 2.53333h; Industry scale;

upstream raw materials:

(1S)-(S)-pinanediol 1-bis(trimethylsilyl)amino-3-methylbutane-1-boronate

trifluoroacetic acid

1,1,1-trimethyl-N-{(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}-N-(trimethylsilyl)silanamine

Downstream raw materials:

(1S,2S,3R,5S)-pinanediol N-BOC-L-phenylalanine-L-leucine boronate