TERT-BUTYL (2S)-2-BENZYL-4-OXOPIPERIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL (2S)-2-BENZYL-4-OXOPIPERIDINE-1-CARBOXYLATE
• CAS No.: 1212330-54-5
• Molecular Formula: C17H23NO3
• Molecular Weight: 289.37
• Hs Code.: 2933399090
• Mol file: 1212330-54-5.mol

Synonyms:(2S)-2-BENZYL-4-OXOPIPERIDINE, N-BOC PROTECTED;TERT-BUTYL (2S)-2-BENZYL-4-OXOPIPERIDINE-1-CARBOXYLATE

Chemical Property of TERT-BUTYL (2S)-2-BENZYL-4-OXOPIPERIDINE-1-CARBOXYLATE

Chemical Property:

• Boiling Point: 409.0±38.0 °C(Predicted)
• PKA: -1.58±0.40(Predicted)
• PSA: 46.61000
• Density: 1.115±0.06 g/cm3(Predicted)
• LogP: 3.13560

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl (2S)-2-benzyl-4-oxopiperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL (2S)-2-BENZYL-4-OXOPIPERIDINE-1-CARBOXYLATE

There total 8 articles about TERT-BUTYL (2S)-2-BENZYL-4-OXOPIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-2-(phenylmethyl)-4-piperidinone (193469-44-2) + tert-butyldicarbonate (34619-03-9) → (+/-)-1,1-dimethylethyl 4-oxo-2-(phenylmethyl)-1-piperidinecarboxylate (193480-28-3,1212330-54-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 48h;

Reference yield: 91.0%

2-benzyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (313950-40-2) → (+/-)-1,1-dimethylethyl 4-oxo-2-(phenylmethyl)-1-piperidinecarboxylate (193480-28-3,1212330-54-5)

Guidance literature:

With zinc; In acetic acid; at 50 ℃; for 12h;

DOI:10.1021/ol006589o

Reference yield:

(+/-)-2-(phenylmethyl)-4-piperidinone (193469-44-2) + di-tert-butyl dicarbonate (24424-99-5) → (+/-)-1,1-dimethylethyl 4-oxo-2-(phenylmethyl)-1-piperidinecarboxylate (193480-28-3,1212330-54-5)

Guidance literature:

In CH₂Cl₂ (500 mo); water;

upstream raw materials:

2-benzyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

4-methoxypyridine

di-tert-butyl dicarbonate

2-Benzyl-2,3-dihydro-1H-pyridin-4-one

Downstream raw materials:

tert-butyl 6-benzyl-4-(((trifluoromethyl)sulfonyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate

tert-butyl 6-benzyl-4-(1-methyl-2-oxo-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)-5,6-dihydropyridine-1(2H)-carboxylate

tert-butyl 2-benzyl-4-(1-methyl-2-oxo-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)piperidine-1-carboxylate

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