(1S,4S)-2-benzyl-2,5-diazabicyclo[2.2.1]heptane-2HCl

Base Information

• Chemical Name: (1S,4S)-2-benzyl-2,5-diazabicyclo[2.2.1]heptane-2HCl
• CAS No.: 1217827-86-5
• Molecular Formula: C₁₂H₁₆N₂*2ClH
• Molecular Weight: 261.194
• Mol file: 1217827-86-5.mol

Synonyms:(1S,4S)-2-benzyl-2,5-diazabicyclo[2.2.1]heptane-2HCl;(1S,4S)-2-Benzyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride-rel

Chemical Property of (1S,4S)-2-benzyl-2,5-diazabicyclo[2.2.1]heptane-2HCl

Chemical Property:

• PSA: 15.27000
• LogP: 3.10340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1S,4S)-2-Benzyl-2,5-diazabicyclo[2.2.1]heptaneDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,4S)-2-benzyl-2,5-diazabicyclo[2.2.1]heptane-2HCl

There total 11 articles about (1S,4S)-2-benzyl-2,5-diazabicyclo[2.2.1]heptane-2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate → 2-benzyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride (1217827-86-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield: 99.0%

(1R,4S)-tert-butyl 5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate → (1S,4R)-2-benzyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride (1217827-86-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 12h;

Reference yield: 99.0%

→ 2-benzyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride (1217827-86-5)

Guidance literature:

upstream raw materials:

(2S,4S)-N-(tert-butoxycarbonyl)-4-(p-toluenesulfonyloxy)-2-<(p-toluenesulfonyloxy)methyl>pyrrolidine

tert-butyl (2S,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine-1-carboxylate

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

4R-4-hydroxyproline

Refernces

• 1、 -. "Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase". . . Retrieved 2017/01/23.
• 2、 -. "HDAC INHIBITORS AND USES THEREOF". Page/Page column 49. . Retrieved 2010/01/29.