(1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid

Base Information

• Chemical Name: (1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid
• CAS No.: 868364-63-0
• Molecular Formula: C10H17NO4
• Molecular Weight: 215.24628

Synonyms:(1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid

Chemical Property of (1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid

Chemical Property:

• Melting Point: 117℃ (ethyl ether hexane )

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

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Technology Process of (1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid

There total 10 articles about (1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl (-)-(1R,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylate (868364-62-9,951173-24-3) → (-)-(1R,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid (868364-63-0,951173-22-1,951173-25-4,951173-34-5,951173-39-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 3h;

DOI:10.1021/ol300689e

Reference yield: 96.0%

(4S,5R)-N-[(1R,2S)-2-(t-butyloxycarbonylamino)cyclobutanecarbonyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one (1333084-20-0) → (-)-(1R,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid (868364-63-0,951173-22-1,951173-25-4,951173-34-5,951173-39-0)

Guidance literature:

With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 5h;

DOI:10.1007/s00726-011-0918-y

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (1R,2S)-cis-2-amino-cyclobutane-1-carboxylic acid (221158-95-8,84585-76-2,84585-77-3,951173-26-5) → (-)-(1R,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid (868364-63-0,951173-22-1,951173-25-4,951173-34-5,951173-39-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 4h;

DOI:10.1055/s-2007-983759

upstream raw materials:

methyl (-)-(1R,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylate

di-tert-butyl dicarbonate

(1R,2S)-cis-2-amino-cyclobutane-1-carboxylic acid

(+/-)-cis-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid

Downstream raw materials:

methyl (-)-(1R,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylate

(-)-(1S,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid

benzyl tert-butyl (1S,2S)-cyclobutane-1,2-diylbiscarbamate

tert-butyl N-[(1S,2S)-2-aminocyclobutyl]carbamate

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