Brocrinat

Base Information

Chemical Name:Brocrinat
CAS No.:72481-99-3
Molecular Formula:C15H9 Br F N O4
Molecular Weight:366.14
Hs Code.:
Mol file:72481-99-3.mol

Synonyms:Aceticacid, [[7-bromo-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]- (9CI); 1,2-Benzisoxazole,acetic acid deriv.; Brocrinat; HP 3522; HP 522; P 78-3522

Suppliers and Price of Brocrinat

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BROCRINAT 95.00%
5MG
$ 505.01

Total 5 raw suppliers

Chemical Property of Brocrinat

Chemical Property:

Vapor Pressure:3.37E-12mmHg at 25°C
Boiling Point:533.2°C at 760 mmHg
Flash Point:276.3°C
PSA：72.56000
Density:1.661g/cm³
LogP:3.85980

Purity/Quality:

99% ^*data from raw suppliers

BROCRINAT 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Brocrinat

There total 10 articles about Brocrinat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl {[7-bromo-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetate

: 72481-99-3
<<7-bromo-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>oxy>acetic acid

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 90 ℃; for 1.5h; Yield given;
DOI:10.1021/jm00343a008

Reference yield:

: 3119-88-8
2'-fluoro-2-hydroxy-4-methoxybenzophenone

: 72481-99-3
<<7-bromo-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>oxy>acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / hydroxylamine hydrochloride, pyridine / 24 h / Heating

2: 85 percent / 1 h / Heating

3: 90 percent / sodium hydride / dimethylformamide / 0.67 h / 30 °C

4: 1.) 2.2 M n-butyllithium, 2.) bromine / 1.) THF, -40 deg C, 2 h

5: pyridine hydrochloride / 2 h / 180 °C

6: K₂CO₃ / dimethylformamide / 1.) 60 deg C, 2 h, 2.) from 60 deg C to RT, overnight

7: aq. NaOH / dimethylformamide / 1.5 h / 90 °C

With pyridine; sodium hydroxide; n-butyllithium; hydroxylamine hydrochloride; bromine; pyridine hydrochloride; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008

Reference yield:

: 72483-09-1
3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole

: 72481-99-3
<<7-bromo-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>oxy>acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 2.2 M n-butyllithium, 2.) bromine / 1.) THF, -40 deg C, 2 h

2: pyridine hydrochloride / 2 h / 180 °C

3: K₂CO₃ / dimethylformamide / 1.) 60 deg C, 2 h, 2.) from 60 deg C to RT, overnight

4: aq. NaOH / dimethylformamide / 1.5 h / 90 °C

With sodium hydroxide; n-butyllithium; bromine; pyridine hydrochloride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008