3-FLUORO-2-IODOBENZONITRILE

Base Information

• Chemical Name: 3-FLUORO-2-IODOBENZONITRILE
• CAS No.: 916792-62-6
• Molecular Formula: C7H3FIN
• Molecular Weight: 247.01
• Hs Code.: 2926907090
• Mol file: 916792-62-6.mol

Synonyms:3-FLUORO-2-IODOBENZONITRILE

Chemical Property of 3-FLUORO-2-IODOBENZONITRILE

Chemical Property:

• PSA: 23.79000
• LogP: 2.30198
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

3-Fluoro-2-iodobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-2-IODOBENZONITRILE

There total 2 articles about 3-FLUORO-2-IODOBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(3-fluoro-2-iodophenyl)-4,4-dimethyl-2-oxazoline → 2-iodo-3-fluorobenzonitrile (916792-62-6)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In neat (no solvent); at 0 - 50 ℃; for 5h; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.202103700

Reference yield: 68.0%

m-Fluorobenzonitrile (403-54-3) → 2-iodo-3-fluorobenzonitrile (916792-62-6)

Guidance literature:

m-Fluorobenzonitrile; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

With iodine; In tetrahydrofuran; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02572

Reference yield: 16.0%

2-iodo-3-fluorobenzonitrile (916792-62-6) + 1,1-diphenyl-2-propyn-1-ol (3923-52-2) → 3-fluoro-2-(3-hydroxy-3,3-diphenylprop-1-yn-1-yl)benzonitrile

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In tetrahydrofuran; at 50 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.joc.7b00958

upstream raw materials:

m-Fluorobenzonitrile

Downstream raw materials:

3-fluoro-2-(pyrimidin-2-yl)benzonitrile

3-fluoro-2-(pyrimidin-2-yl)benzoic acid

2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-fluoro-2-pyrimidin-2-ylphenyl)carbonyl]octahydropyrrolo[3,4-c]pyrrole

3-(4,6-dimethylpyrimidin-2-yl)-8-{[3-fluoro-2-(pyrimidin-2-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]octane