PYRIDO[3,4-B]PYRAZINE, 7-CHLORO-

Base Information

• Chemical Name: PYRIDO[3,4-B]PYRAZINE, 7-CHLORO-
• CAS No.: 93049-39-9
• Molecular Formula: C7H4ClN3
• Molecular Weight: 165.582
• Hs Code.: 2933990090
• Mol file: 93049-39-9.mol

Synonyms:PYRIDO[3,4-B]PYRAZINE, 7-CHLORO-;7-Chloropyrido[3,4-b]pyrazine;7-Chloro-6-azaquinoxaline

Chemical Property of PYRIDO[3,4-B]PYRAZINE, 7-CHLORO-

Chemical Property:

• Vapor Pressure: 0.000872mmHg at 25°C
• Boiling Point: 314.2°C at 760 mmHg
• PKA: 1.44±0.30(Predicted)
• Flash Point: 173°C
• PSA: 38.67000
• Density: 1.437g/cm³
• LogP: 1.67820
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

7-Chloropyrido[3,4-b]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRIDO[3,4-B]PYRAZINE, 7-CHLORO-

There total 2 articles about PYRIDO[3,4-B]PYRAZINE, 7-CHLORO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloro-pyridine-3,4-diamine (89182-17-2) + Glyoxal (131543-46-9,107-22-2) → 7-chloro-pyrido[3,4-b]pyrazine (93049-39-9)

Guidance literature:

In ethanol; water; for 18h;

Reference yield:

→ 7-chloro-pyrido[3,4-b]pyrazine (93049-39-9)

Guidance literature:

aus 2-Chlor-4,5-diamino-pyridin und polymeres Glyoxalmonohydrat in sd.EtOH (2 Std.);

DOI:10.1039/jr9630005156

Reference yield: 77.0%

7-chloro-pyrido[3,4-b]pyrazine (93049-39-9) + 3-Formylphenylboronic acid (87199-16-4) → 3-(pyrido[3,4-b]pyrazin-7-yl)benzaldehyde (1225280-70-5)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 140 ℃; for 0.5h; Sealed tube; Microwave irradiation;

upstream raw materials:

6-chloro-pyridine-3,4-diamine

Glyoxal

Downstream raw materials:

7-[3-(pyrrolidin-1-ylmethyl)phenyl]pyrido[3,4-b]pyrazine

7-[3-(piperidin-1-ylmethyl)phenyl]pyrido[3,4-b]pyrazine

3-(pyrido[3,4-b]pyrazin-7-yl)benzaldehyde