Cyclopentanecarbonyl fluoride, 1-(trifluoromethyl)- (9CI)

Base Information

• Chemical Name: Cyclopentanecarbonyl fluoride, 1-(trifluoromethyl)- (9CI)
• CAS No.: 277756-41-9
• Molecular Formula: C₇H₈F₄O
• Molecular Weight: 184.134
• Mol file: 277756-41-9.mol

Synonyms:Cyclopentanecarbonyl fluoride, 1-(trifluoromethyl)- (9CI)

Chemical Property of Cyclopentanecarbonyl fluoride, 1-(trifluoromethyl)- (9CI)

Chemical Property:

• Boiling Point: 142.4±35.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.311±0.06 g/cm3(Predicted)
• LogP: 2.60520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarbonyl fluoride, 1-(trifluoromethyl)- (9CI)

There total 2 articles about Cyclopentanecarbonyl fluoride, 1-(trifluoromethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

cyclopentane-1,1-dicarboxylic acid (5802-65-3) → 1-trifluoromethyl-cyclopentanecarbonyl fluoride (277756-41-9)

Guidance literature:

With sulfur tetrafluoride; at 30 ℃; for 3h;

DOI:10.1016/S0022-1139(99)00233-X

Reference yield:

cyclopentane-1,1-dicarboxylic acid diethyl ester (4167-77-5) → 1-trifluoromethyl-cyclopentanecarbonyl fluoride (277756-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH; H₂O / 48 h / 20 °C

2: 44 percent / SF₄ / 3 h / 30 °C

With sodium hydroxide; sulfur tetrafluoride; water; 1: Hydrolysis / 2: Fluorination;

DOI:10.1016/S0022-1139(99)00233-X

Reference yield:

1-trifluoromethyl-cyclopentanecarbonyl fluoride (277756-41-9) → 1-Methyl-1-(trifluoromethyl)cyclopentane (371917-22-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / LiAlH₄ / diethyl ether / 2 h / 5 °C

2: 51 percent / MeI; P(OPh)3 / 24 h / Heating

3: 65 percent / AIBN; Bu₃SnH / benzene / 3 h / 60 °C

With triphenyl phosphite; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; methyl iodide; In diethyl ether; benzene;

DOI:10.1016/S0022-1139(01)00353-0

upstream raw materials:

cyclopentane-1,1-dicarboxylic acid

cyclopentane-1,1-dicarboxylic acid diethyl ester

Downstream raw materials:

1-Methyl-1-(trifluoromethyl)cyclopentane