UROCORTIN (HUMAN)

Base Information

• Chemical Name: UROCORTIN (HUMAN)
• CAS No.: 176591-49-4
• Molecular Formula: C204H337 N63 O64
• Molecular Weight: 1131.4
• Mol file: 176591-49-4.mol

Synonyms:Humanurocortin; Human urocortin I; L-Valinamide, L-a-aspartyl-L-asparaginyl-L-prolyl-L-seryl-L-leucyl-L-seryl-L-isoleucyl-L-a-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-threonyl-L-leucyl-L-leucyl-L-a-glutamyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-glutaminyl-L-seryl-L-glutaminyl-L-arginyl-L-a-glutamyl-L-arginyl-L-alanyl-L-a-glutamyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-phenylalanyl-L-a-aspartyl-L-seryl-

Chemical Property of UROCORTIN (HUMAN)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: −20°C

Purity/Quality:

99%, ^*data from raw suppliers

Urocortin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Biological functions: Ucn1 stimulates adrenocorticotropic hormone (ACTH) secretion both in vivo and in vitro while Ucn2 and Ucn3 do not stimulate ACTH secretion. This effect of Ucn1 on the pituitary is probably mediated by CRHR1, as is CRH. Ucn1 is more potent than CRH in suppressing food intake. Ucn-specific effects are considered to be mediated by CRHR2. ICV injection of Ucn1 increases whole body oxygen consumption and body temperature in the rat. Ucn1 has been reported to participate in vascular inflammation, and to function as an anxiolytic in stress response. Ucn2 and Ucn3 may be responsible for the effects of stress on appetite and anxiety in the brain. Ucn2 blocks the suppression of gastric antral contractions induced by lipopolysaccharide in freely moving conscious rats.
• Uses: Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.
• Clinical Use: Ucn1 levels are high in the synovial fluid of patients with rheumatoid arthritis. Ucn1 has been linked to a reduction in inflammation and bone erosion in a mouse model of rheumatoid arthritis.

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