5-Cbz-1-oxa-5-azaspiro[2.4]heptane

Base Information

• Chemical Name: 5-Cbz-1-oxa-5-azaspiro[2.4]heptane
• CAS No.: 790704-73-3
• Molecular Formula: C13H15NO3
• Molecular Weight: 233.267
• Mol file: 790704-73-3.mol

Synonyms:5-Cbz-1-oxa-5-azaspiro[2.4]heptane;benzyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate

Chemical Property of 5-Cbz-1-oxa-5-azaspiro[2.4]heptane

Chemical Property:

• PSA: 42.07000
• LogP: 1.73580

Purity/Quality:

97% ^*data from raw suppliers

5-Cbz-1-oxa-5-azaspiro[2.4]heptane 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Cbz-1-oxa-5-azaspiro[2.4]heptane

There total 1 articles about 5-Cbz-1-oxa-5-azaspiro[2.4]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-methylenepyrrolidine-1-carboxylic acid benzyl ester (150543-35-4) → 1-oxa-5-azaspiro[2.4]heptane-5-carboxylic acid benzyl ester (790704-73-3)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 87.0%

(R)‐3‐(3‐fluoro‐4‐hydroxyphenyl)‐5‐(hydroxymethyl)oxazolidin‐2‐one (1025097-50-0) + 1-oxa-5-azaspiro[2.4]heptane-5-carboxylic acid benzyl ester (790704-73-3) → (RS)-3-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester (1025097-75-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield: 87.0%

(R)‐3‐(3‐fluoro‐4‐hydroxyphenyl)‐5‐(hydroxymethyl)oxazolidin‐2‐one (1025097-50-0) + 1-oxa-5-azaspiro[2.4]heptane-5-carboxylic acid benzyl ester (790704-73-3) → (S)-3-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

upstream raw materials:

3-methylenepyrrolidine-1-carboxylic acid benzyl ester

Downstream raw materials:

(RS)-3-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

(R)-3-[3-fluoro-4-((RS)-3-hydroxy-pyrrolidin-3-ylmethoxy)-phenyl]-5-hydroxymethyl-oxazolidin-2-one

1-cyclopropyl-6-fluoro-7-{(RS)-3-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-3-hydroxy-pyrrolidin-1-yl}-4-oxo-1,4dihydro-quinoline-3-carboxylic acid