2-Fluoro-6-nitrophenylacetic acid

Base Information

• Chemical Name: 2-Fluoro-6-nitrophenylacetic acid
• CAS No.: 136916-19-3
• Molecular Formula: C8H6FNO4
• Molecular Weight: 199.138
• Hs Code.: 2916399090
• Mol file: 136916-19-3.mol

Synonyms:2-Fluoro-6-nitrophenylacetic acid;2-(2-Fluoro-6-nitrophenyl)acetic acid

Chemical Property of 2-Fluoro-6-nitrophenylacetic acid

Chemical Property:

• Boiling Point: 344.4±27.0 °C(Predicted)
• PKA: 3.66±0.10(Predicted)
• PSA: 83.12000
• Density: 1.498±0.06 g/cm3(Predicted)
• LogP: 1.88420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Fluoro-6-nitrophenyl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-6-nitrophenylacetic acid

There total 4 articles about 2-Fluoro-6-nitrophenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

diethyl (2-fluoro-6-nitrophenyl)malonate → (2-fluoro-6-nitrophenyl)acetic acid (136916-19-3)

Guidance literature:

With hydrogenchloride; In water; acetic acid; for 6h; Reflux;

DOI:10.1016/j.bmc.2015.10.002

Reference yield: 54.0%

2-(2-fluoro-6-nitrophenyl)malonic acid dimethyl ester (866209-62-3) → (2-fluoro-6-nitrophenyl)acetic acid (136916-19-3)

Guidance literature:

With hydrogenchloride; water; for 4h; Heating / reflux;

Reference yield: 54.0%

2-(3-fluoro-2-nitrophenyl)malonic acid dimethyl ester (872141-24-7) → (2-fluoro-6-nitrophenyl)acetic acid (136916-19-3)

Guidance literature:

With hydrogenchloride; water; for 4h; Heating / reflux;

upstream raw materials:

2-(2-fluoro-6-nitrophenyl)malonic acid dimethyl ester

2-(3-fluoro-2-nitrophenyl)malonic acid dimethyl ester

1,2-difluoro-3-nitrobenzene

Downstream raw materials:

4-fluoro-1,3-dihydro-2H-indol-2-one

7-fluoro-1,3-dihydro-indol-2-one

C₈H₈FNO₂

methyl 1-(2-fluoro-6-nitrophenyl)cyclobutanecarboxylate