Etravirine-d6

Base Information

Chemical Name:Etravirine-d6
CAS No.:1142096-06-7
Molecular Formula:C20H15BrN6O
Molecular Weight:435.2767
Hs Code.:
Mol file:1142096-06-7.mol

Synonyms:4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-(dimethyl-d6)benzonitrile;Etravirine-d6;R 165335-d6;TMC 125-d6;Etravirine-d8

Suppliers and Price of Etravirine-d6

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Etravirine-d8
1mg
$ 496.00

TRC
Etravirine-d8
1mg
$ 215.00

Cayman Chemical
Etravirine-d6
1mg
$ 375.00

American Custom Chemicals Corporation
ETRAVIRINE-D6 95.00%
10MG
$ 2194.50

American Custom Chemicals Corporation
ETRAVIRINE-D6 95.00%
1MG
$ 779.63

Total 3 raw suppliers

Chemical Property of Etravirine-d6

Chemical Property:

Melting Point:262-263°C
Storage Temp.:Refrigerator
Solubility.:Acetone (Slightly), DMSO (Slightly), Chloroform and Methanol Mixture (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Etravirine-d8 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection. As a novel labelled HIV reverse transcriptase inhibitor,Etravirine-d8 is useful in treatment of HIV infection

Technology Process of Etravirine-d6

There total 8 articles about Etravirine-d6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1316315-43-1
4-(5-bromo-6-chloro-2-(4-cyanophenylamino)-pyrimidin-4-yloxy)-3,5-[⁽²⁾H₆]dimethylbenzonitrile

: 1142096-06-7
C₂₀H₉⁽²⁾H₆BrN₆O

Guidance literature:: With ammonia; In 1,4-dioxane; at 150 ℃; for 24h;
DOI:10.1002/jlcr.1882

Reference yield:

: 1316315-41-9
4-bromo-2,6-[⁽²⁾H₆]dimethylphenol

: 1142096-06-7
C₂₀H₉⁽²⁾H₆BrN₆O

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 5 h / 154 °C

2.1: sodium hydride / 1,4-dioxane / 0.03 h / 20 °C

2.2: 0.17 h / 20 °C

2.3: 6 h / 155 °C

3.1: ammonia / 1,4-dioxane / 24 h / 150 °C

With ammonia; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/jlcr.1882

Reference yield:

: 2,6-[⁽²⁾H₆]dimethylphenol

: 1142096-06-7
C₂₀H₉⁽²⁾H₆BrN₆O

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine; acetic acid / 0.33 h / 20 °C / Cooling with ice

2.1: N,N-dimethyl-formamide / 5 h / 154 °C

3.1: sodium hydride / 1,4-dioxane / 0.03 h / 20 °C

3.2: 0.17 h / 20 °C

3.3: 6 h / 155 °C

4.1: ammonia / 1,4-dioxane / 24 h / 150 °C

With ammonia; bromine; sodium hydride; acetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/jlcr.1882