(S)-2-Methyl-3,5-dioxo-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (S)-2-Methyl-3,5-dioxo-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS No.: 890709-66-7
• Molecular Formula: C₁₀H₁₅NO₄
• Molecular Weight: 213.233
• Mol file: 890709-66-7.mol

Synonyms:(S)-2-Methyl-3,5-dioxo-pyrrolidine-1-carboxylic acid tert-butyl ester;(S)-tert-Butyl 2-Methyl-3,5-dioxopyrrolidine-1-carboxylate

Chemical Property of (S)-2-Methyl-3,5-dioxo-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• PSA: 63.68000
• LogP: 1.04930
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

(S)-2-Methyl-3,5-dioxo-pyrrolidine-1-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

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Technology Process of (S)-2-Methyl-3,5-dioxo-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 7 articles about (S)-2-Methyl-3,5-dioxo-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl N-[(2S)-1-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-1-oxopropan-2-yl]carbamate → tert-butyl (2S)-2-methyl-3,5-dioxo-pyrrolidine-1-carboxylate (890709-66-7)

Guidance literature:

In ethyl acetate; for 0.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2011.07.078

Reference yield: 85.0%

5-(N-tert-butoxycarbonylalanyl)meldrum’s acid → tert-butyl (2S)-2-methyl-3,5-dioxo-pyrrolidine-1-carboxylate (890709-66-7)

Guidance literature:

In ethyl acetate; for 0.5h; Reflux;

DOI:10.1021/jm500215s

Reference yield:

cycl-isopropylidene malonate (2033-24-1) + L-N-Boc-Ala (15761-38-3) → tert-butyl (2S)-2-methyl-3,5-dioxo-pyrrolidine-1-carboxylate (890709-66-7)

Guidance literature:

cycl-isopropylidene malonate; L-N-Boc-Ala; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

In ethyl acetate; for 0.5h; Heating;

DOI:10.1021/ol060500i

upstream raw materials:

cycl-isopropylidene malonate

L-N-Boc-Ala

di-tert-butyl dicarbonate

tert-butyl N-[(1S)-2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-hydroxy-1-methylethyl]carbamate

Downstream raw materials:

C₁₇H₂₁NO₆S

(S)-5-benzyl-4-(tert-butoxy)-1-((S)-1-((S)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one

[(S)-1-Benzyl-2-((S)-3-ethoxy-2-methyl-5-oxo-2,5-dihydro-pyrrol-1-yl)-2-oxo-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

(5S)-5-methyl-2,4-dioxopyrrolidine

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