[2-Methyl-2-(methylamino)cyclopentyl]methanol

Base Information

• Chemical Name: [2-Methyl-2-(methylamino)cyclopentyl]methanol
• CAS No.: 421765-87-9
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.229
• DSSTox Substance ID: DTXSID00694302
• Mol file: 421765-87-9.mol

Synonyms:DTXSID00694302;421765-87-9;[2-Methyl-2-(methylamino)cyclopentyl]methanol

Chemical Property of [2-Methyl-2-(methylamino)cyclopentyl]methanol

Chemical Property:

• Vapor Pressure: 0.0375mmHg at 25°C
• Boiling Point: 212.9°C at 760 mmHg
• Flash Point: 69.9°C
• PSA: 32.26000
• Density: 0.96g/cm³
• LogP: 1.14780
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 116

Purity/Quality:

98%min ^*data from raw suppliers

(2-METHYL-2-CIS-METHYLAMINO-CYCLOPENTYL)-METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCCC1CO)NC

Technology Process of [2-Methyl-2-(methylamino)cyclopentyl]methanol

There total 3 articles about [2-Methyl-2-(methylamino)cyclopentyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hept-6-en-2-one (21889-88-3) → N-Methyl-1-methyl-cis-2-hydroxymethyl-cyclopentylamin; 1t-Methylamino-1r-methyl-2t-hydroxymethyl-cyclopentan (421765-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene

2: H₂ / Pd-C / ethanol

With hydrogen; palladium on activated charcoal; In ethanol; toluene;

DOI:10.1021/ja01072a031

Reference yield:

1,6a-dimethyl-hexahydro-cyclopenta[c]isoxazole (23884-98-2,23884-99-3,69575-65-1) → N-Methyl-1-methyl-cis-2-hydroxymethyl-cyclopentylamin; 1t-Methylamino-1r-methyl-2t-hydroxymethyl-cyclopentan (421765-87-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/ja01072a031

Reference yield:

2-acetyl-hex-5-enoic acid ethyl ester (104196-99-8,42185-42-2) → N-Methyl-1-methyl-cis-2-hydroxymethyl-cyclopentylamin; 1t-Methylamino-1r-methyl-2t-hydroxymethyl-cyclopentan (421765-87-9)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) (saponification), (ii) (decarboxylation)

2: toluene

3: H₂ / Pd-C / ethanol

With hydrogen; palladium on activated charcoal; In ethanol; toluene;

DOI:10.1021/ja01072a031

upstream raw materials:

1,6a-dimethyl-hexahydro-cyclopenta[c]isoxazole

hept-6-en-2-one

2-acetyl-hex-5-enoic acid ethyl ester