Mannostatin A, Hydrochloride

Base Information

• Chemical Name: Mannostatin A, Hydrochloride
• CAS No.: 134235-13-5
• Molecular Formula: C5H11NO3
• Molecular Weight: 215.701
• Mol file: 134235-13-5.mol

Synonyms:1D-(1,2,3,4/5)-2,3,4-trihydroxy-5-(methylsulfanyl)cyclopentane-1-ammonium chloride;1-cyclohexyl-TIQ;(+)-mannostatin A monohydrochloride;1-cy-hexyl-TIQ;mannostatin A hydrochloride;1-Cyclohexyl-1,2,3,4-tetrahydro-isoquinoline;

Chemical Property of Mannostatin A, Hydrochloride

Chemical Property:

• PSA: 112.01000
• LogP: -1.15810
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

MannostatinA,Hydrochloride(~90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A potent glycosidase inhibitor that blocks Golgi processing mannosidase ll more effectively than swainsonine. Mannostatin A, Hydrochloride is a potent glycosidase inhibitor that blocks Golgi processing mannosidase ll more effectively than swainsonine.

Technology Process of Mannostatin A, Hydrochloride

There total 41 articles about Mannostatin A, Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,2R,3R,4R,5S)-1-(methylthio)-2,3,4-triacetoxy-5-(N-((R)-acetoxyphenylacetyl)amino)cyclopentane (134153-74-5) → 1D-(1,2,3,4/5)-2,3,4-trihydroxy-5-(methylsulfanyl)cyclopentane-1-ammonium chloride (134235-13-5)

Guidance literature:

With hydrogenchloride; In methanol; at 70 ℃; for 22h;

DOI:10.1021/ja00081a017

Reference yield: 100.0%

(1R,2R,3R,4S,5R)-4-acetylamino-5-methylthiocyclopentane-1,2,3-triol (129467-31-8) → 1D-(1,2,3,4/5)-2,3,4-trihydroxy-5-(methylsulfanyl)cyclopentane-1-ammonium chloride (134235-13-5)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 12h;

DOI:10.1021/jo980855i

Reference yield: 100.0%

1D-(1,2,3,4/5)-4-acetamido-1,2,3-tri-O-acetyl-5-(methylsulfanyl)cyclopentane-1,2,3-triol (171032-11-4) → 1D-(1,2,3,4/5)-2,3,4-trihydroxy-5-(methylsulfanyl)cyclopentane-1-ammonium chloride (134235-13-5)

Guidance literature:

With hydrogenchloride; at 80 ℃; for 1.5h;

upstream raw materials:

(1R,2R,3R,4R,5S)-1-(methylthio)-2,3,4-triacetoxy-5-(N-((R)-acetoxyphenylacetyl)amino)cyclopentane

C₁₂H₂₁NO₃S

1D-(1,2,3,4/5)-4-acetamido-1,2,3-tri-O-acetyl-5-(methylsulfanyl)cyclopentane-1,2,3-triol

(1R,2R,3R,4S,5R)-4-acetylamino-5-methylthiocyclopentane-1,2,3-triol

Downstream raw materials:

mannostatin A

4-[4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)-benzyloxycarbonyl]amino-5-(methylsulfanyl)cyclopentane-1,2,3-triol