Etiroxate Carboxylic Acid

Base Information

Chemical Name:Etiroxate Carboxylic Acid
CAS No.:3414-34-4
Molecular Formula:C₁₆H₁₃I₄NO₄
Molecular Weight:790.902
Hs Code.:
ChEMBL ID:CHEMBL153476
DSSTox Substance ID:DTXSID70604993
Mol file:3414-34-4.mol

Synonyms:Etiroxate Carboxylic Acid;3414-34-4;2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-methylpropanoic acid;2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-2-methylpropanoic acid;CHEMBL153476;SCHEMBL11607195;DTXSID70604993;AKOS030253213;J-019465;O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-alpha-methyltyrosine

Suppliers and Price of Etiroxate Carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Etiroxate Carboxylic Acid
25mg
$ 446.00

TRC
EtiroxateCarboxylicAcid
100mg
$ 555.00

Total 4 raw suppliers

Chemical Property of Etiroxate Carboxylic Acid

Chemical Property:

Vapor Pressure:2.61E-14mmHg at 25°C
Boiling Point:580.3°C at 760 mmHg
Flash Point:304.8°C
PSA：92.78000
Density:2.543g/cm³
LogP:5.64770
Solubility.:Aqueous Sodium Hydroxide,
XLogP3:2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:790.7023
Heavy Atom Count:25
Complexity:461

Purity/Quality:

97% ^*data from raw suppliers

Etiroxate Carboxylic Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=CC(=C(C(=C1)I)OC2=CC(=C(C(=C2)I)O)I)I)(C(=O)O)N
Uses Thyroxin derivative inhibiting glutamate dehydrogenase, isocitrate dehydrogenase, alcohol dehydrogenase, rat liver mitochondrial phosphorylation and electron transfer. Administration also induces hypothyroid state.Etiroxate Carboxylic Acid is suitable for IDH (isocitrate dehydrogenase) related research. Thyroxin derivative inhibiting glutamate dehydrogenase, isocitrate dehydrogenase, alcohol dehydrogenase, rat liver mitochondrial phosphorylation and electron transfer. Administration also induces hypothyroid state.

Technology Process of Etiroxate Carboxylic Acid

There total 8 articles about Etiroxate Carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7373-67-3
N-Acetyl-4-hydroxy-3,5-dijod-α-methyl-phenylalanin

: 3414-34-4,19118-59-3
α-methylthyroxine

Guidance literature:: Multi-step reaction with 4 steps

1: TsOH / CHCl₃

2: Et₃N, Cu / methanol

3: HI, AcOH

4: I₂, KI, aq. EtNH₂

With hydrogen iodide; iodine; copper; toluene-4-sulfonic acid; ethylamine; acetic acid; triethylamine; potassium iodide; In methanol; chloroform;
DOI:10.1021/jm00319a003

Reference yield:

: 189447-43-6,5680-96-6
2-Acetylamino-3-(4-hydroxy-3,5-diiodo-phenyl)-2-methyl-propionic acid ethyl ester

: 3414-34-4,19118-59-3
α-methylthyroxine

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N, Cu / methanol

2: HI, AcOH

3: I₂, KI, aq. EtNH₂

With hydrogen iodide; iodine; copper; ethylamine; acetic acid; triethylamine; potassium iodide; In methanol;
DOI:10.1021/jm00319a003

Reference yield:

: 7373-66-2
N-Trifluor-acetyl-4-hydroxy-3,5-diiod-α-methyl-phenylalanin-aethylester

: 3414-34-4,19118-59-3
α-methylthyroxine

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N, Cu / methanol

2: HI, AcOH

3: I₂, KI, aq. EtNH₂

With hydrogen iodide; iodine; copper; ethylamine; acetic acid; triethylamine; potassium iodide; In methanol;
DOI:10.1021/jm00319a003