1-[(3aR,8aR)-tetrahydro-2,2-diMethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]- Piperidine

Base Information

• Chemical Name: 1-[(3aR,8aR)-tetrahydro-2,2-diMethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]- Piperidine
• CAS No.: 213843-95-9
• Molecular Formula: C₃₆H₃₈NO₄P
• Molecular Weight: 579.676
• Mol file: 213843-95-9.mol

Synonyms:1-[(3aR,8aR)-tetrahydro-2,2-diMethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]- Piperidine

Chemical Property of 1-[(3aR,8aR)-tetrahydro-2,2-diMethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]- Piperidine

Chemical Property:

• Boiling Point: 613.6±55.0 °C(Predicted)
• PKA: 2.04±0.20(Predicted)
• PSA: 53.75000
• LogP: 8.09160

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-[(3aR,8aR)-tetrahydro-2,2-diMethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]- Piperidine

There total 2 articles about 1-[(3aR,8aR)-tetrahydro-2,2-diMethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]- Piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

piperidine (110-89-4) + (R,R)-TADDOL (93379-48-7) → 1-((3aR,8aR)-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine-6-yl)piperidine (213843-95-9,582300-11-6)

Guidance literature:

(R,R)-TADDOL; With triethylamine; phosphorus trichloride; In dichloromethane; at -50 - -20 ℃; for 1.91667h;

piperidine; With triethylamine; In dichloromethane; at -50 - 20 ℃; for 12h;

DOI:10.1002/hlca.201200147

Reference yield: 90.0%

piperidine (110-89-4) + (3aR,8aR)-6-chloro-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine (299917-90-1) → 1-((3aR,8aR)-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine-6-yl)piperidine (213843-95-9,582300-11-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Molecular sieve; Inert atmosphere;

DOI:10.1002/chem.201500352

Reference yield: 75.0%

1-((3aR,8aR)-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine-6-yl)piperidine (213843-95-9,582300-11-6) → (3aR,8aR)-2,2-dimethyl-4,4,8,8-tetraphenyl-6-(piperidin-1-yl)tetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine 6-selenide

Guidance literature:

With selenium; In chloroform; Reflux;

DOI:10.1055/s-0036-1591982

upstream raw materials:

piperidine

(R,R)-TADDOL

(3aR,8aR)-6-chloro-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine

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