AKOS JY2082718

Base Information

• Chemical Name: AKOS JY2082718
• CAS No.: 90766-47-5
• Molecular Formula: C10H8BrNO2
• Molecular Weight: 254.083
• Hs Code.: 2933990090
• Mol file: 90766-47-5.mol

Synonyms:AKOS JY2082718;5-Bromo-2-carboxy-1-methyl-1H-indole

Chemical Property of AKOS JY2082718

Chemical Property:

• PSA: 42.23000
• LogP: 2.63900

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-1-methyl-1H-indole-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AKOS JY2082718

There total 5 articles about AKOS JY2082718 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 5-bromo-1-methyl-1H-indole-2-carboxylate (860457-91-6) → 5-bromo-1-methyl-1H-indole-2-carboxylic acid (90766-47-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃; for 4h;

DOI:10.1021/acs.orglett.9b02498

Reference yield:

5-bromo-2-indolecarboxylic acid (7254-19-5) → 5-bromo-1-methyl-1H-indole-2-carboxylic acid (90766-47-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Inert atmosphere; Reflux

2: potassium hydroxide / N,N-dimethyl-formamide / 0.33 h / 20 °C

3: sodium hydroxide / water; tetrahydrofuran; ethanol / 4 h / 20 °C

With sulfuric acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.9b02498

Reference yield:

5-bromo-1H-indole-2-carboxylic acid methyl ester (210345-56-5) → 5-bromo-1-methyl-1H-indole-2-carboxylic acid (90766-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 0.33 h / 20 °C

2: sodium hydroxide / water; tetrahydrofuran; ethanol / 4 h / 20 °C

With potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.9b02498

upstream raw materials:

methyl 5-bromo-1-methyl-1H-indole-2-carboxylate

5-bromo-1-methyl-1H-indole-2-carboxylic acid ethyl ester

5-bromo-2-indolecarboxylic acid

5-bromo-1H-indole-2-carboxylic acid methyl ester

Downstream raw materials:

methyl 2-{[(5-bromo-1-methyl-1H-indol-2-yl)carbonyl]amino}-5-chlorobenzoate

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