2-METHYLPYRAZOLO[1,5-A]QUINAZOLIN-5(4H)-ONE

Base Information

• Chemical Name: 2-METHYLPYRAZOLO[1,5-A]QUINAZOLIN-5(4H)-ONE
• CAS No.: 25468-50-2
• Molecular Formula: C₁₁H₉N₃O
• Molecular Weight: 199.212
• Hs Code.: 2933990090
• Mol file: 25468-50-2.mol

Synonyms:2-METHYLPYRAZOLO[1,5-A]QUINAZOLIN-5(4H)-ONE;4,5-Dihydro-2-methyl-5-oxopyrazolo[1,5-a]quinazoline

Chemical Property of 2-METHYLPYRAZOLO[1,5-A]QUINAZOLIN-5(4H)-ONE

Chemical Property:

• Vapor Pressure: 0.008mmHg at 25°C
• Melting Point: 288-290°C
• Boiling Point: 266.77°C at 760 mmHg
• PKA: 12.71±0.20(Predicted)
• Flash Point: 115.139°C
• PSA: 50.16000
• Density: 1.415g/cm³
• LogP: 1.48420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Methylpyrazolo[1,5-a]quinazolin-5(4H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYLPYRAZOLO[1,5-A]QUINAZOLIN-5(4H)-ONE

There total 6 articles about 2-METHYLPYRAZOLO[1,5-A]QUINAZOLIN-5(4H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-bromobenzoic acid methyl ester (610-94-6) + 3-amino-5-methylpyrazole (31230-17-8) → 2-methylpyrazolo[1,5-a]quinazolin-5(4H)-one (25468-50-2)

Guidance literature:

With copper(l) iodide; caesium carbonate; In water; at 100 ℃; for 6h; chemoselective reaction; Inert atmosphere;

DOI:10.1080/00397911.2015.1083032

Reference yield: 70.0%

Cyanoaceton (2469-99-0) + 2-hydrazinobenzoic acid hydrochloride (33906-30-8,52356-01-1) → 2-methylpyrazolo[1,5-a]quinazolin-5(4H)-one (25468-50-2)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; Reflux;

Reference yield:

C11H10FN3O → 2-methylpyrazolo[1,5-a]quinazolin-5(4H)-one (25468-50-2)

Guidance literature:

In N,N-dimethyl-formamide; at 140 - 145 ℃;

DOI:10.1016/j.tetlet.2015.01.146

upstream raw materials:

2-Fluorobenzoyl chloride

2-bromobenzoic acid methyl ester

3-amino-5-methylpyrazole

Cyanoaceton

Downstream raw materials:

5-chloro-2-methylpyrazolo[1,5-a]quinazoline

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