J 147

Base Information

Chemical Name:J 147
CAS No.:1146963-51-0
Molecular Formula:C18H17F3N2O2
Molecular Weight:350.3349896
Hs Code.:
Mol file:1146963-51-0.mol

Synonyms:J 147;J147/J-147;2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide;J 147 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

Suppliers and Price of J 147

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
J147
10mg
$ 165.00

Tocris
J147 ≥99%(HPLC)
50
$ 745.00

Tocris
J147 ≥99%(HPLC)
10
$ 182.00

Medical Isotopes, Inc.
J147
100 mg
$ 650.00

Medical Isotopes, Inc.
J147
1 g
$ 2200.00

DC Chemicals
J-147 >98%
1 g
$ 800.00

DC Chemicals
J-147 >98%
250 mg
$ 400.00

Crysdot
J-147 98+%
50mg
$ 497.00

ChemScene
J-147 99.87%
5mg
$ 90.00

ChemScene
J-147 99.87%
10mg
$ 120.00

Total 101 raw suppliers

Chemical Property of J 147

Chemical Property:

Boiling Point:412.8±55.0 °C(Predicted)
PKA:0.80±0.50(Predicted)
PSA：41.90000
Density:1.18±0.1 g/cm3(Predicted)
LogP:4.24140
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

J147 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques. J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer''s disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer''s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.

Technology Process of J 147

There total 2 articles about J 147 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 391646-35-8
1-(2,4-dimethylphenyl)-2-(3-methoxybenzylidene)hydrazine

: 407-25-0
trifluoroacetic anhydride

: 1146963-51-0
2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.11.031

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1146963-51-0
2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / ethanol; water / 0.33 h / 100 °C

2: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With sodium acetate; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.11.031