4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

Base Information

Chemical Name:4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER
CAS No.:778646-95-0
Molecular Formula:C12H22N2O4
Molecular Weight:258.318
Hs Code.:2933399090
Mol file:778646-95-0.mol

Synonyms:4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER;(2R,4R)-4-amino-1,2-Piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester

Suppliers and Price of 4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
1-O-tert-butyl2-O-methyl4-aminopiperidine-1,2-dicarboxylate 95%+
5g
$ 4687.00

Alichem
1-(Tert-butyl)2-methyl(2r,4r)-4-aminopiperidine-1,2-dicarboxylate
1g
$ 1696.86

Alichem
1-(Tert-butyl)2-methyl(2r,4r)-4-aminopiperidine-1,2-dicarboxylate
250mg
$ 706.58

Total 7 raw suppliers

Chemical Property of 4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

Chemical Property:

Boiling Point:338.3±42.0 °C(Predicted)
PKA:9.66±0.40(Predicted)
PSA：81.86000
Density:1.123±0.06 g/cm3(Predicted)
LogP:1.52440

Purity/Quality:

97% ^*data from raw suppliers

1-O-tert-butyl2-O-methyl4-aminopiperidine-1,2-dicarboxylate 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

There total 3 articles about 4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1095173-08-2
(2R,4R)-1-tert-butyl 2-methyl 4-azidopiperidine-1,2-dicarboxylate

: 778646-95-0
(2R,4R)-1-tert-butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 20h; under 2585.81 Torr;

Reference yield:

: 321744-26-7,181269-87-4
N-Boc-4-hydroxy-2-piperidine carboxylic acid methyl ester

: 778646-95-0
(2R,4R)-1-tert-butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap / 5 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 18 h / 60 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 h / 20 °C / 2585.81 Torr

With pyridine; dmap; sodium azide; palladium 10% on activated carbon; hydrogen; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ml2002423

Reference yield:

: 405229-64-3
(2R,4S)-1-tert-butyl 2-methyl 4-(methylsulfonyloxy)piperidine-1,2-dicarboxylate

: 778646-95-0
(2R,4R)-1-tert-butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h / 60 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 h / 20 °C / 2585.81 Torr

With sodium azide; palladium 10% on activated carbon; hydrogen; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ml2002423