6-(4-Chlorophenyl)-3-methylimidazo[2,1-B]thiazole-5-carboxaldehyde

Base Information

Chemical Name:6-(4-Chlorophenyl)-3-methylimidazo[2,1-B]thiazole-5-carboxaldehyde
CAS No.:178449-64-4
Molecular Formula:C13H9ClN2OS
Molecular Weight:0
Hs Code.:
DSSTox Substance ID:DTXSID701165991
Mol file:178449-64-4.mol

Synonyms:178449-64-4;6-(4-CHLOROPHENYL)-3-METHYLIMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE;ITXOUUVOKRGNSM-UHFFFAOYSA-N;DTXSID701165991;6-(4-CHLOROPHENYL)-3-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE;AKOS005145058

Suppliers and Price of 6-(4-Chlorophenyl)-3-methylimidazo[2,1-B]thiazole-5-carboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 6-(4-Chlorophenyl)-3-methylimidazo[2,1-B]thiazole-5-carboxaldehyde

Chemical Property:

Melting Point:140 - 142 °C (methanol)
PSA：62.61000
LogP:3.83710
XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:276.0124118
Heavy Atom Count:18
Complexity:322

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CSC2=NC(=C(N12)C=O)C3=CC=C(C=C3)Cl

Technology Process of 6-(4-Chlorophenyl)-3-methylimidazo[2,1-B]thiazole-5-carboxaldehyde

There total 3 articles about 6-(4-Chlorophenyl)-3-methylimidazo[2,1-B]thiazole-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 25968-22-3
6-(4-chlorophenyl)-3-methylimidazo[2,1-b]thiazole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 178449-64-4
6-(4-Chloro-phenyl)-3-methyl-imidazo[2,1-b]thiazole-5-carbaldehyde

Guidance literature:: With trichlorophosphate; at 60 ℃; for 4h;

Reference yield:

: 536-38-9
4-chlorobenzoylmethyl bromide

: 178449-64-4
6-(4-Chloro-phenyl)-3-methyl-imidazo[2,1-b]thiazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / ethanol / 6 h / Heating

2: 75 percent / sodium carbonate / H₂O

3: 71 percent / phosphoryl chloride / 4 h / 60 °C

With sodium carbonate; trichlorophosphate; In ethanol; water; 3: Vilsmeyer-Haack reaction;

Reference yield:

: 6-(4-chloro-phenyl)-3-methyl-7H-imidazo[2,1-b]thiazol-4-ylium; bromide

: 178449-64-4
6-(4-Chloro-phenyl)-3-methyl-imidazo[2,1-b]thiazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / sodium carbonate / H₂O

2: 71 percent / phosphoryl chloride / 4 h / 60 °C

With sodium carbonate; trichlorophosphate; In water; 2: Vilsmeyer-Haack reaction;