2-(2,3-dichlorophenyl)-4-thiazoleacetamide

Base Information

• Chemical Name: 2-(2,3-dichlorophenyl)-4-thiazoleacetamide
• CAS No.: 78743-10-9
• Molecular Formula: C₁₁H₈Cl₂N₂OS
• Molecular Weight: 0
• Mol file: 78743-10-9.mol

Synonyms:2-(2,3-dichlorophenyl)-4-thiazoleacetamide

Chemical Property of 2-(2,3-dichlorophenyl)-4-thiazoleacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,3-dichlorophenyl)-4-thiazoleacetamide

There total 2 articles about 2-(2,3-dichlorophenyl)-4-thiazoleacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

[2-(2,3-Dichloro-phenyl)-thiazol-4-yl]-acetic acid ethyl ester (78782-93-1) → 2-[2-(2,3-Dichloro-phenyl)-thiazol-4-yl]-acetamide (78743-10-9)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; for 120h; Ambient temperature;

DOI:10.1021/jm00359a015

Reference yield:

2,3-dichlorobenzothioamide (84863-83-2) → 2-[2-(2,3-Dichloro-phenyl)-thiazol-4-yl]-acetamide (78743-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / ethanol / 4 h / Heating

2: 85 percent / NH₄OH / dioxane / 120 h / Ambient temperature

With ammonium hydroxide; In 1,4-dioxane; ethanol;

DOI:10.1021/jm00359a015

Reference yield: 49.0%

oxalic acid diethyl ester (95-92-1) + 2-[2-(2,3-Dichloro-phenyl)-thiazol-4-yl]-acetamide (78743-10-9) → 3-[2-(2,3-Dichloro-phenyl)-thiazol-4-yl]-4-hydroxy-pyrrole-2,5-dione (84864-12-0)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00359a015

upstream raw materials:

[2-(2,3-Dichloro-phenyl)-thiazol-4-yl]-acetic acid ethyl ester

2,3-dichlorobenzothioamide

Downstream raw materials:

3-[2-(2,3-Dichloro-phenyl)-thiazol-4-yl]-4-hydroxy-pyrrole-2,5-dione